Fig. 5.

Production of NO and NOS₃ expression in the presence of cytokines. a A significant increase in production of NO was noted in the presence of IL1-β, compared with other cytokines. b Exposure to IL1-β and IFN-γ produced a significant increase in NOS₃ expression, whereas IFN-α had no effect on the expression of NOS₃ (n = 3, **P < 0.01, ***P < 0.001). All values are expressed as ± SE. Abbreviations: IFN-γ, interferon-γ; IL1-β, interleukin 1β; NS, not significant; TNF-α, tumor necrosis factor-α