Table 3.
Disease Probabilities (%) and Proportion of CRC Case Subjects (%) (95% CI) by Age 80 in High- and Low-Risk Groups
| LDPred-Derived PRS | LDPred-Derived PRS + FamilyHx | ||||
|---|---|---|---|---|---|
| PRS (%) | Disease Prob (95% CI) (%) | Prop of Cases (95% CI) (%) | PRS or Pos FamHx (%)a | Disease Prob (95% CI) (%) | Prop of Cases (95% CI) (%) |
| Top 10 | 6.4 (5.5–7.3) | 23.4 (19.8–27.0) | 18.0 | 5.9 (5.2–6.6) | 39.3 (38.9–39.8) |
| 20 | 5.4 (4.8–6.1) | 39.7 (32.7–42.8) | 26.7 | 5.3 (4.7–5.8) | 51.7 (49.1–54.2) |
| 30 | 4.6 (4.1–5.1) | 50.3 (46.6–55.6) | 35.6 | 4.7 (4.2–5.1) | 60.7 (57.5–63.9) |
| PRS (%) | Disease Prob (95% CI) (%) | Prop of Cases (95% CI) (%) | PRS and Neg FamHx (%)b | Disease Prob (95% CI) (%) | Prop of Cases (95% CI) (%) |
| Bottom 10 | 0.9 (0.5–1.2) | 3.3 (2.0–4.6) | 9.1 | 0.7 (0.3–0.9) | 2.3 (1.9–2.8) |
| 20 | 1.1 (0.8–1.5) | 8.1 (7.5–8.7) | 18.4 | 0.9 (0.7–1.2) | 6.1 (5.4–7.1) |
| 30 | 1.4 (1.0–1.6) | 15.3 (14.3–16.5) | 27.6 | 1.0 (0.9–1.2) | 10.1 (8.9–12.0) |
a
PRS or Pos. FamHx: individuals were in the top x% of PRS or had a positive family history.
b
PRS and negative FamHx: individuals were in the bottom x% and had a negative family history.