Figure 1.

Association of Each Disease PRS with Cause-Specific Mortality in the Full Cohort

For each disease, we evaluated the association between the disease PRS and mortality from the disease based on sex-specific Cox proportional hazards models of age at death. Deaths from other causes were treated as censoring events. Some causes did not have enough deaths to yield stable estimates, i.e., <6 deaths; in these cases, estimates are not provided. Each PRS was standardized to have unit variance so the estimates correspond to the HR per SD of the PRS. The horizontal lines indicate 95% confidence intervals. CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; HR, hazard ratio; SD, standard deviation; PRS, polygenic risk score.