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. 2020 Aug 25;8:781. doi: 10.3389/fcell.2020.00781

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Copyright © 2020 Ma, Chan, Rubab, Chan and Chan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ECM regulation of cellular plasticity. (A) Cells respond to molecular signals and mechanical properties of the ECM through receptors and ion channels on the cell membrane. (B–D) Models of regulation of cellular plasticity. (B) Cells responding to local changes in the ECM environment to induce changes in behavior. (C) Cells receive new cues when migrating into a new environment. (D) A transitional matrix is temporarily remodeled from the homeostatic native ECM to induce changes to cellular plasticity, which then reverts back to the native ECM once the cellular process is complete.