Table 1.
Baseline demographics and clinical characteristics of patient population according to stage of melanoma
| Baseline demographics and clinical characteristics | Stage IIB or IIC melanoma (n = 1174 patients) | Stage IIIA melanoma (n = 142 patients) |
|---|---|---|
| Age in years, mean (SD) | 79.1 (9.3) | 71.9 (11.0) |
| Sex, n (%) | ||
| Male | 748 (64) | 79 (56) |
| Female | 426 (36) | 63 (44) |
| Race, n (%) | ||
| White | 1152 (98) | 142 (100) |
| Other | 22 (2) | 0 |
| Geographic location, n (%) | ||
| West | 493 (42) | 60 (42) |
| Northeast | 267 (23) | 30 (21) |
| Midwest | 234 (20) | 31 (22) |
| South | 169 (14) | 21 (15) |
| Missing | 11 (1) | 0 |
| Metropolitan status, n (%) | ||
| Large metropolitan | 594 (51) | 76 (54) |
| Metropolitan/urban | 425 (36) | 54 (38) |
| Less urban/rural | 155 (13) | 12 (8) |
| Tumor sizea, n (%) | ||
| T1 | 0 | < 11 (< 8) |
| T2 | 0 | < 11 (< 8) |
| T3 | 461 (39) | 98 (69) |
| T4 | 713 (61) | > 33 (> 23) |
| Ulceration, n (%) | ||
| Yes | 860 (73) | NA |
| No | 312 (27) | NA |
| N staginga, n (%) | ||
| N0 | 1174 (100) | 0 |
| N1 | 0 | 123 (87) |
| N2 | 0 | 19 (13) |
| Histologic subtype, n (%) | ||
| Nodular | 399 (34) | 25 (18) |
| Superficial spreading | 140 (12) | 43 (30) |
| Lentigo maligna | 34 (3) | 0 |
| Acral lentiginous | 28 (2) | < 11 (< 8) |
| Amelanotic | 12 (1) | < 11 (< 8) |
| Other uncommon | 150 (13) | < 11 (< 8) |
| Unspecified | 411 (35) | 64 (45) |
| CCI, mean (SD) | 0.7 (1.3) | 0.5 (1.2) |
| Comorbidities, n (%) | ||
| Diabetes (with chronic complications) | 198 (17) | 19 (13) |
| Congestive heart failure | 109 (9) | < 11 (< 8) |
| Chronic pulmonary disease | 104 (9) | < 11 (< 8) |
| Renal disease | 83 (7) | < 11 (< 8) |
| Myocardial infarction | 49 (4) | < 11 (< 8) |
| Cerebrovascular disease | 44 (4) | < 11 (< 8) |
| Peripheral vascular disease | 35 (3) | < 11 (< 8) |
| Rheumatic disease | 21 (2) | < 11 (< 8) |
| Autoimmune disease | 15 (1) | < 11 (< 8) |
CCI Charlson Comorbidity Index, NA not applicable, SD standard deviation
aAmerican Joint Committee on Cancer, seventh edition [7]