Figure 3.

The Loss-of-Function Intolerance of Tissue-Specific Genes Conditional on High Promoter CpG-Density (o/e CpG Ratio) and Promoter EZH2 Binding

(A) The median number of ENCODE ChIP-seq experiments (out of 14 total) where an EZH2 peak is detected, shown separately for tissue-specific ($\tau >0.6$) and broadly expressed ($\tau <0.6$) genes, within each quartile of promoter CpG density. The quartiles are labeled from 1-4, with 1 being the most CpG-poor and 4 the most CpG-rich.

(B) The LOEUF distributions of tissue-specific genes with high-CpG-density (top 25%) promoters, stratified according to whether their promoters show EZH2 peaks in at least 2 ENCODE experiments, or in less than 2 experiments.