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Phosphatase and tensin homolog (PTEN) is a target gene of miR-221 and miR-222 in IOMM-Lee cells. (A,B) Significantly decreased luciferase activities were revealed after the cotransfection of miR-221 mimics or miR-222 mimics and psi-check2-PTEN in dual luciferase reporter assay. (C,D) Western blot analysis exhibited that the expression of PTEN was positively correlated with radiation dose but negatively correlated with miR-221/222 expression.
