TABLE 1.
Associations between podocyte injury and miRNA expression levels in cultured podocyte cells and rodent models of diabetic nephropathy.
| miRNAs | Expression patterns | Sample | Predicted target mRNA | References |
| miRNA-16-5p | ↓ | Cultured human podocyte | VEGFA | Duan et al., 2019 |
| miRNA-20b | ↑ | Conditionally immortalized cultured mouse podocytes | SIRT7 | Wang et al., 2017 |
| miRNA-21 | ↑ | Conditionally immortalized cultured mouse podocytes. Kidney (KK-Ay mice received high-fat diets). Serum (KK-Ay mice received high-fat diets) | TIMP3 Cdc25a Cdk6 | Kolling et al., 2017; Chen et al., 2018; Wang et al., 2018 |
| miRNA-23b | ↓ | Cultured mouse podocytes. Kidney (STZ-induced diabetic nephropathy mice, db/db). | G3BP2 | Zhao et al., 2016 |
| miRNA-25 | ↓ | Cultured mouse podocytes. Kidney (STZ-induced diabetic nephropathy mice, db/db). Serum (db/db). | Cdc42 | Liu et al., 2017 |
| miRNA-27a | ↑ | Conditionally immortalized cultured murine podocyte. Glomeruli (STZ-induced diabetic nephropathy rats). Plasma (STZ-induced diabetic nephropathy rats). | PPAR-γ | Zhou et al., 2017 |
| miRNA-29a | ↓ | Primary cultured mouse podocytes. Immortalized cultured mouse podocyte. Glomeruli (STZ-induced diabetic nephropathy mice). | HDAC | Lin et al., 2014 |
| miRNA-29c | ↑ | Conditionally immortalized cultured mouse podocytes. Glomeruli (db/db). | TTP Spry1 | Long et al., 2011; Guo et al., 2017 |
| miRNA-30s | ↓ | Conditionally immortalized cultured mouse podocytes. Glomeruli (STZ-induced diabetic nephropathy rats). | MTDH | Liu et al., 2016 |
| miRNA-34a | ↓ | Conditionally immortalized cultured mouse podocytes. | Notch-1 | Zhang et al., 2016 |
| miRNA-34c | ↓ | Conditionally immortalized cultured mouse podocytes. | Notch1 Jagged1 | Liu et al., 2015 |
| miRNA-93 | ↓ | Conditionally immortalized cultured mouse podocytes. Glomeruli (db/db). | VEGF-A Msk2 | Long et al., 2010; Badal et al., 2016 |
| miRNA-130a-3p | ↓ | Conditionally immortalized cultured mouse podocytes. | TNF-α | Jiang et al., 2018 |
| miRNA-134-5p | ↑ | Conditionally immortalized cultured human podocyte. Kidney (db/db). | Bcl-2 | Qian et al., 2018 |
| miRNA-145-5p | ↓ | Cultured mouse podocytes. | Notch1 | Wei et al., 2020 |
| miRNA-146a | ↓ | Glomeruli. | ErbB4 Notch-1 | Lee et al., 2017 |
| miRNA-193a | ↑ | Conditionally immortalized cultured human podocytes. | APOL1 | Mishra et al., 2018 |
| miRNA-195 | ↑ | Conditionally immortalized cultured mouse podocyte Glomeruli (db/db). | Bcl2 | Chen et al., 2011 |
| miRNA-217 | ↑ | Cultured mouse podocytes. | PTEN | Sun et al., 2017 |
| miRNA-218 | ↑ | Conditionally immortalized cultured mouse podocytes. | HO-1 | Yang et al., 2016 |
| miRNA-301a-3p | ↓ | Conditionally immortalized cultured mouse podocytes. | TNF-α | Jiang et al., 2018 |
| miRNA-423-5p | ↓ | Conditionally immortalized cultured mouse podocytes. | Nox4 | Xu et al., 2018 |
| miRNA-503 | ↑ | Cultured mouse podocytes. | E2F3 | Zha et al., 2019 |
| miRNA-770-5p | ↑ | Cultured mouse podocyte. | TRIAP1 | Zhang et al., 2019 |
| miRNA-874 | ↓ | Conditionally immortalized cultured mouse podocytes. Kidney (STZ-induced diabetic nephropathy rats). | TLR-4 | Yao et al., 2018 |