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. 2020 Aug 25;11:881. doi: 10.3389/fneur.2020.00881

Figure 1.

Figure 1

Respiratory chain complex and citrate synthase activities. (A) NADH dehydrogenase activity (complex I, CI; Mann–Whitney test: p = 0.003) and (B) cytochrome c oxidase (complex IV, CIV; Mann–Whitney test: p = 0.114) normalized to citrate synthase (CS) activity in non-manifesting [leucine-rich repeat kinase-2 (LRRK2)+/PD−, n = 3] and manifesting carriers (LRRK2+/PD+, n = 3) of the G2019S mutation in LRRK2. (C) CS activity relative to cell number, with one sample serving as an internal standard (Mann–Whitney test: p = 0.001). Experiments performed on six (CI) or three (CIV and CS) independent replicates. **p < 0.01.