Table 7.
Top 10 gene ontologies and KEGG pathways of differentially expressed genes
| Category | Term | Count | % | P value |
|---|---|---|---|---|
| BP | GO: 0007268~chemical synaptic transmission | 19 | 4.241071429 | 3.86E-06 |
| MF | GO: 0015276~ligand-gated ion channel activity | 8 | 1.785714286 | 6.26E-06 |
| CC | GO: 0005576~extracellular region | 62 | 13.83928571 | 9.28E-06 |
| BP | GO: 0035094~response to nicotine | 8 | 1.785714286 | 1.08E-05 |
| CC | GO: 0045211~postsynaptic membrane | 17 | 3.794642857 | 1.40E-05 |
| CC | GO: 0005615~extracellular space | 53 | 11.83035714 | 2.78E-05 |
| MF | GO: 0005230~extracellular ligand-gated ion channel activity | 7 | 1.5625 | 4.40E-05 |
| BP | GO: 0007586~digestion | 9 | 2.008928571 | 5.29E-05 |
| MF | GO: 0005179~hormone activity | 10 | 2.232142857 | 1.13E-04 |
| BP | GO: 0007271~synaptic transmission, cholinergic | 7 | 1.5625 | 1.16E-04 |
| KEGG pathway | hsa04080: Neuroactive ligand-receptor interaction | 30 | 6.696428571 | 1.09E-14 |
| KEGG pathway | hsa04972: Pancreatic secretion | 10 | 2.232142857 | 5.19E-05 |
| KEGG pathway | hsa04723: Retrograde endocannabinoid signaling | 9 | 2.008928571 | 5.48E-04 |
| KEGG pathway | hsa05033: Nicotine addiction | 6 | 1.339285714 | 8.05E-04 |
| KEGG pathway | hsa04727: GABAergic synapse | 8 | 1.785714286 | 9.70E-04 |
| KEGG pathway | hsa04974: Protein digestion and absorption | 8 | 1.785714286 | 0.001191854 |
| KEGG pathway | hsa05032: Morphine addiction | 7 | 1.5625 | 0.006772348 |
| KEGG pathway | hsa05218: Melanoma | 5 | 1.116071429 | 0.042731956 |
| KEGG pathway | hsa04725: Cholinergic synapse | 6 | 1.339285714 | 0.055498778 |
| KEGG pathway | hsa00053: Ascorbate and aldarate metabolism | 3 | 0.669642857 | 0.089180199 |
Note: KEGG, Kyoto Encyclopedia of Genes and Genomes, BP: biological process, CC: cellular component, MF: molecular function, FDR: false discovery rate.