Table 2.
Univariate and multivariate logistic regression analysis for the associated risk factors for developing lung metastases in patients diagnosed with cervical cancer between 2010-2015
| Subject characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age (years) | ||||
| <40 | Reference | 1.000 | Reference | 1.000 |
| 40-64 | 3.010 (2.387-3.795) | <0.001 | 2.357 (1.349-4.117) | 0.003 |
| ≥65 | 4.918 (3.844-6.292) | <0.001 | 3.485 (1.945-6.243) | <0.001 |
| Ethnicity | ||||
| White | Reference | 1.000 | Reference | 1.000 |
| Black | 1.228 (1.018-1.482) | 0.032 | 0.882 (0.586-1.327) | 0.546 |
| Others | 0.895 (0.705-1.137) | 0.363 | 0.859 (0.510-1.447) | 0.568 |
| Unknown | NA | NA | NA | NA |
| Marital status | ||||
| Married | Reference | 1.000 | Reference | 1.000 |
| Unmarried | 1.285 (1.110-1.488) | 0.001 | 1.025 (0.766-1.372) | 0.867 |
| Unknown | NA | NA | NA | NA |
| T-stage | ||||
| T1 | Reference | 1.000 | Reference | 1.000 |
| T2 | 4.067 (3.114-5.312) | <0.001 | 1.479 (0.920-2.377) | 0.106 |
| T3 | 13.788 (10.863-17.502) | <0.001 | 3.592 (2.290-5.635) | <0.001 |
| T4 | 21.315 (15.949-28.487) | <0.001 | 4.053 (2.329-7.053) | <0.001 |
| N-stage | ||||
| N0 | Reference | 1.000 | Reference | 1.000 |
| N1 | 6.522 (5.540-7.679) | <0.001 | 2.556 (1.894-3.451) | <0.001 |
| Unknown | NA | NA | NA | NA |
| Histology | ||||
| Squamous | Reference | 1.000 | Reference | 1.000 |
| Adenocarcinoma | 0.888 (0.740-1.066) | 0.204 | 1.882 (1.328-2.666) | <0.001 |
| Others | 2.114 (1.775-2.518) | <0.001 | 1.664 (1.092-2.534) | 0.018 |
| Grade | ||||
| G1 | Reference | 1.000 | Reference | 1.000 |
| G2 | 3.392 (2.021-5.694) | <0.001 | 2.172 (0.945-4.988) | 0.068 |
| G3 | 9.268 (5.602-15.331) | <0.001 | 3.373 (1.496-7.605) | 0.003 |
| G4 | 11.735 (6.454-21.348) | <0.001 | 2.818 (1.046-7.591) | 0.041 |
| Unknown | NA | NA | NA | NA |
| Bone metastases | ||||
| None | Reference | 1.000 | Reference | 1.000 |
| Yes | 20.539 (16.756-25.176) | <0.001 | 3.894 (2.539-5.973) | <0.001 |
| Unknown | NA | NA | NA | NA |
| Liver metastases | ||||
| None | Reference | 1.000 | Reference | 1.000 |
| Yes | 29.696 (24.067-36.640) | <0.001 | 7.925 (5.062-12.407) | <0.001 |
| Unknown | NA | NA | NA | NA |
| Brain metastases | ||||
| None | Reference | 1.000 | Reference | 1.000 |
| Yes | 30.752 (19.657-48.111) | <0.001 | 4.215 (1.531-11.607) | 0.005 |
| Unknown | NA | NA | NA | NA |
| Surg (Prim) | ||||
| None | Reference | 1.000 | Reference | 1.000 |
| Yes | 0.070 (0.055-0.089) | <0.001 | 0.276 (0.180-0.424) | <0.001 |
| Unknown | NA | NA | NA | NA |
NA= not available, Surg (Prim) = surgical treatment of primary site.