Table 2.
Correlation analysis between CA4 and related genes and markers of immune cells in GEPIA.
| Description | Gene markers | KIRC | LGG | LUAD | UVM | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumor | Normal | Tumor | Tumor | Normal | Tumor | |||||||||||||
| R | P | R | P | R | P | R | P | R | P | R | P | |||||||
| Monocyte | CD86 | -0.17 | **** | 0.23 | 0.051 | -0.33 | **** | 0.053 | 0.24 | -0.19 | 0.15 | -0.25 | * | |||||
| CD115 (CSF1R) | -0.059 | 0.17 | 0.23 | * | -0.28 | **** | 0.079 | 0.082 | -0.28 | * | -0.15 | 0.2 | ||||||
| TAM | CCL2 | 0.32 | **** | -0.24 | * | -0.33 | **** | -0.014 | 0.76 | 0.0011 | 0.99 | 0.057 | 0.62 | |||||
| CD68 | -0.13 | ** | 0.4 | *** | -0.38 | **** | 0.18 | **** | -0.19 | 0.15 | 0.13 | 0.25 | ||||||
| IL10 | -0.074 | 0.092 | 0.0092 | 0.94 | -0.37 | **** | 0.16 | *** | -0.35 | ** | -0.13 | 0.24 | ||||||
| M1 Macrophage | INOS (NOS2) | 0.46 | **** | 0.068 | 0.57 | 0.27 | **** | 0.3 | **** | 0.46 | *** | 0.038 | 0.74 | |||||
| IRF5 | -0.1 | * | -0.62 | **** | -0.28 | **** | 0.095 | * | -0.28 | * | -0.27 | * | ||||||
| COX2 (PTGS2) | 0.051 | 0.24 | -0.35 | ** | 0.027 | 0.54 | -0.088 | 0.052 | -0.0043 | 0.97 | -0.28 | * | ||||||
| M2 Macrophage | CD163 | -0.1 | * | 0.12 | 0.31 | -0.4 | **** | 0.14 | ** | -0.2 | 0.13 | -0.17 | 0.14 | |||||
| VSIG4 | -0.12 | ** | 0.15 | 0.21 | -0.38 | **** | 0.17 | *** | -0.25 | 0.061 | -0.2 | 0.074 | ||||||
| MS4A4A | -0.069 | 0.12 | 0.26 | * | -0.38 | **** | 0.2 | **** | -0.24 | 0.071 | -0.11 | 0.35 | ||||||
| Th1 | T-bet (TBX21) | 0.19 | **** | 0.36 | ** | -0.22 | **** | 0.2 | **** | 0.43 | *** | -0.34 | ** | |||||
| STAT4 | -0.027 | 0.54 | 0.17 | 0.14 | 0.41 | **** | 0.079 | 0.085 | 0.2 | 0.14 | -0.19 | 0.1 | ||||||
| STAT1 | -0.069 | 0.12 | -0.29 | * | -0.22 | **** | -0.015 | 0.73 | 0.11 | 0.41 | -0.27 | * | ||||||
| IFN-γ (IFNG) | -0.24 | **** | 0.02 | 0.87 | -0.1 | * | -0.0043 | 0.92 | 0.059 | 0.66 | -0.25 | * | ||||||
| TNF-α (TNF) | 0.046 | 0.29 | -0.078 | 0.51 | -0.15 | *** | 0.02 | 0.66 | -0.2 | 0.13 | -0.33 | ** | ||||||
| Th2 | GATA3 | -0.021 | 0.64 | -0.41 | *** | -0.23 | **** | 0.013 | 0.77 | 0.39 | ** | -0.32 | ** | |||||
| STAT6 | 0.25 | **** | -0.4 | *** | 0.052 | 0.24 | 0.28 | **** | 0.19 | 0.15 | -0.2 | 0.083 | ||||||
| STAT5A | -0.1 | * | 0.017 | 0.89 | -0.26 | **** | 0.13 | ** | -0.047 | 0.72 | 0.28 | * | ||||||
| IL13 | 0.12 | ** | -0.067 | 0.58 | -0.018 | 0.68 | 0.069 | 0.13 | -0.079 | 0.55 | -0.34 | ** | ||||||
| Treg | FOXP3 | -0.33 | **** | -0.16 | 0.18 | 0.22 | **** | -0.019 | 0.68 | -0.17 | 0.19 | -0.22 | 0.052 | |||||
| CCR8 | -0.22 | **** | 0.21 | 0.074 | -0.061 | 0.16 | 0.043 | 0.34 | -0.15 | 0.26 | -0.26 | * | ||||||
| STAT5B | 0.41 | **** | -0.093 | 0.44 | -0.18 | **** | 0.23 | **** | 0.41 | ** | 0.015 | 0.9 | ||||||
| TGFβ (TGFB1) | -0.11 | * | -0.57 | **** | -0.36 | **** | 0.014 | 0.76 | -0.05 | 0.7 | -0.054 | 0.64 | ||||||
| T cell exhaustion | PD-1 (PDCD1) | -0.2 | **** | 0.39 | *** | -0.3 | **** | 0.0068 | 0.88 | -0.0078 | 0.95 | -0.37 | *** | |||||
| CTLA4 | -0.2 | **** | 0.15 | 0.22 | -0.1 | * | 0.054 | 0.23 | -0.05 | 0.71 | -0.29 | ** | ||||||
| LAG3 | -0.24 | **** | -0.57 | **** | -0.24 | **** | -0.055 | 0.22 | 0.072 | 0.59 | -0.35 | ** | ||||||
| TIM-3 (HAVCR2) | 0.028 | 0.52 | 0.59 | **** | -0.33 | **** | 0.076 | 0.095 | -0.19 | 0.14 | -0.22 | * | ||||||
| GZMB | 0.089 | * | 0.35 | ** | -0.092 | * | -0.047 | 0.3 | 0.43 | *** | -0.29 | ** | ||||||
KIRC, kidney renal clear cell carcinoma; LGG, Brain Lower Grade Glioma; LUAD, lung adenocarcinoma; UVM, uveal melanoma; TAM, tumor-associated macrophage; Th, T helper cell; Treg, regulatory T cell; R, R value of Spearman's correlation.
*p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.