Table 5.
Evaluation of the influence of no cirrhosis/cirrhosis on distant metastasis
| Variables | n = 9284 | Univariate analysis | Logistic multivariate regression | |||
|---|---|---|---|---|---|---|
| M0, No. (%) | M1, No. (%) | P | OR (95%CI) | P | ||
| Sex | Male | 6550 (77.9) | 732 (84.0) | < 0.001 | Reference | |
| Female | 1863 (22.1) | 139 (16.0) | 0.651 (0.538-0.789) | < 0.001 | ||
| Age | <60 | 3436 (40.8) | 412 (47.3) | < 0.001 | Reference | |
| ≥60 | 4977 (59.2) | 459 (52.7) | 0.807 (0.700-0.930) | 0.003 | ||
| Race | White | 5810 (69.1) | 589 (67.6) | 0.009 | Reference | |
| Black‡ | 1029 (12.2) | 138 (15.8) | 1.169 (0.957-1.428) | 0.127 | ||
| Other* | 1526 (18.1) | 142 (16.3) | 0.940 (0.772-1.145) | 0.539 | ||
| Unknown | 48 (0.6) | 2 (0.2) | 0.459 (0.110-1.907) | 0.284 | ||
| Marital Status | Married | 4198 (49.9) | 376 (43.2) | < 0.001 | Reference | |
| Non-married# | 3898 (46.3) | 466 (53.5) | 1.311 (1.132-1.519) | < 0.001 | ||
| Unknown | 317 (3.8) | 29 (3.3) | 0.987 (0.663-1.470) | 0.949 | ||
| Year of diagnosis | 2010-2011 | 2547 (30.3) | 256 (29.4) | 0.811 | - | |
| 2012-2013 | 2858 (34.0) | 295 (33.9) | - | |||
| 2014-2016 | 3008 (35.8) | 320 (36.7) | - | |||
| AFP | Negative | 2201 (26.2) | 111 (12.7) | Reference | ||
| Positive | 5216 (62.0) | 668 (76.7) | 2.530 (2.054-3.116) | < 0.001 | ||
| Borderline | 13 (0.2) | 1 (0.1) | 1.466 (0.189-11.377) | 0.714 | ||
| Unknown | 983 (11.7) | 91 (10.4) | 1.825 (1.368-2.436) | < 0.001 | ||
| Fibrosis | Non-cirrhosis | 1313 (15.6) | 175 (20.1) | < 0.001 | Reference | |
| Cirrhosis | 7100 (84.4) | 696 (79.9) | 0.671 (0.561-0.804) | < 0.001 | ||
‡, Black or African American; *, Includes American Indian/Alaska native, Asian, and Asian/Pacific Islander; #, Includes widowed, never married, divorced, separated, unmarried, and domestic partner; AFP: alpha fetoprotein; OR: odds ratio; CI: confidence interval.