Table 4.
Univariate analysis for risk factors associated with overall survival and disease-free survival
| Overall survival | Disease-free survival | |||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| MUST ≥1 | 1.765 (1.333-2.336) | <0.001* | 1.474 (1.097-1.982) | 0.010* |
| NRS-2002 ≥3 | 1.884 (1.427-2.489) | <0.001* | 1.269 (0.937-1.719) | 0.124 |
| MST ≥2 | 1.632 (1.226-2.173) | 0.001* | 1.446 (1.061-1.971) | 0.020* |
| SNAQ ≥2 | 1.554 (1.135-2.129) | 0.006* | 1.892 (1.370-2.611) | <0.001* |
| Sarcopenia | 2.540 (1.855-3.423) | <0.001* | 2.295 (1.662-3.170) | <0.001* |
| Gender (male/female) | 1.136 (0.819-1.576) | 0.445 | 1.063 (0.756-1.496) | 0.725 |
| Age ≥75 y | 1.744 (1.268-2.398) | 0.001* | 1.296 (0.898-1.870) | 0.165 |
| BMI <18.5 | 1.567 (0.997-2.463) | 0.052 | 1.515 (0.930-2.467) | 0.095 |
| ASA ≥III | 1.620 (1.176-2.232) | 0.003* | 1.661 (1.181-2.337) | 0.004* |
| Charlson comorbidity index ≥1 | 1.056 (0.777-1.437) | 0.726 | 1.240 (0.904-1.701) | 0.183 |
| Anemia | 1.790 (1.355-2.363) | <0.001* | 1.892 (1.408-2.543) | <0.001* |
| Hypoproteinemia | 1.645 (1.221-2.215) | 0.001 | 1.764 (1.290-2.413) | <0.001* |
| Previous abdominal surgery | 0.945 (0.763-1.170) | 0.602 | 1.207 (0.779-1.872) | 0.400 |
| TNM stage | <0.001* | |||
| II/I | 2.627 (1.494-4.620) | 0.001* | 5.802 (2.885-11.668) | <0.001* |
| III/I | 8.502 (5.270-13.717) | <0.001* | 14.994 (7.875-28.549) | <0.001* |
| Tumor differentiation Undifferentiated/Differentiated | 2.404 (1.694-3.413) | <0.001* | 2.813 (1.908-4.147) | <0.001* |
| Tumor location at cardia | 1.191 (0.803-1.766) | 0.384 | 1.145 (0.750-1.745) | 0.531 |
| Type of resection (Total gastrectomy/Subtotal gastrectomy | 2.096 (1.586-2.776) | <0.001* | 2.121 (1.577-2.853) | <0.001* |
| Laparoscopic surgery | 0.453 (0.306-0.672) | <0.001* | 0.504 (0.338-0.751) | 0.001* |
| Combined organ resection | 1.904 (1.252-2.896) | 0.003* | 2.176 (1.415-3.348) | <0.001* |
| Extent of lymph node dissection (D2/D1) | 1.225 (0.805-1.865) | 0.343 | 1.273 (0.807-2.009) | 0.300 |
| Adjuvant chemotherapy | 0.813 (0.616-1.073) | 0.144 | 1.062 (0.788-1.430) | 0.693 |
| Postoperative complications | 0.002* | 0.257 | ||
| Grade II/ No | 1.592 (1.146-2.210) | 0.006* | 1.258 (0.872-1.816) | 0.220 |
| Grade III-V/ No | 1.887 (1.166-3.054) | 0.010* | 1.433 (0.825-2.491) | 0.202 |
*Statistically significant (P < 0.05);
HR, hazard Ratio; CI, confidence interval; BMI, body mass index; ASA, American Society of Anesthesiologists; TNM, tumor-node-metastasis.