Table 5.
Multivariate analysis for risk factors associated with overall survival
| MUST ≥1 | NRS-2002 ≥3 | MST ≥2 | SNAQ ≥2 | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | |
| Nutritional risk | 1.192 (0.878-1.619) | 0.260 | 1.391 (1.029-1.878) | 0.032* | 1.159 (0.859-1.564) | 0.335 | 1.007 (0.852-1.189) | 0.937 |
| Sarcopenia | 1.609 (1.141-2.268) | 0.007* | 1.562 (1.108-2.201) | 0.011* | 1.598 (1.134-2.252) | 0.007* | 1.605 (1.137-2.264) | 0.007* |
| Gender (male/female) | 1.189 (0.846-1.669) | 0.319 | 1.178 (0.840-1.653) | 0.343 | 1.183 (0.843-1.660) | 0.330 | 1.165 (0.831-1.634) | 0.377 |
| Age ≥75 y | 1.042 (0.716-1.515) | 0.831 | 1.022 (0.704-1.484) | 0.909 | 1.030 (0.708-1.498) | 0.877 | 1.042 (0.717-1.514) | 0.829 |
| BMI <18.5 | 1.249 (0.765-2.039) | 0.373 | 1.209 (0.748-1.954) | 0.439 | 1.308 (0.812-2.106) | 0.270 | 1.355 (0.843-2.178) | 0.209 |
| ASA ≥III | 1.129 (0.804-1.586) | 0.485 | 1.110 (0.789-1.562) | 0.548 | 1.118 (0.796-1.570) | 0.520 | 1.118 (0.796-1.569) | 0.520 |
| Anemia | 1.071 (0.779-1.474) | 0.672 | 1.079 (0.785-1.482) | 0.640 | 1.073 (0.779-1.476) | 0.668 | 1.083 (0.787-1.491) | 0.624 |
| Hypoproteinemia | 0.882 (0.624-1.246) | 0.475 | 0.847 (0.599-1.197) | 0.346 | 0.904 (0.642-1.275) | 0.566 | 0.904 (0.639-1.277) | 0.566 |
| Undifferentiated Histologic type | 1.532 (1.058-2.218) | 0.024* | 1.528 (1.056-2.211) | 0.025* | 1.549 (1.070-2.240) | 0.020* | 1.544 (1.067-2.234) | 0.021* |
| TNM stage | <0.001* | <0.001* | <0.001* | |||||
| II/I | 2.623 (1.438-4.784) | 0.002* | 2.619 (1.437-4.776) | 0.002* | 2.638 (1.446-4.812) | 0.002* | 2.688 (1.475-4.898) | 0.001* |
| III/I | 8.059 (4.736-13.711) | <0.001 | 8.265 (4.865-14.040) | <0.001* | 8.131 (4.783-13.821) | <0.001* | 8.306 (4.889-14.114) | <0.001* |
| Total gastrectomy | 1.569 (1.173-2.098) | 0.002* | 1.566 (1.171-2.094) | 0.002* | 1.571 (1.175-2.101) | 0.002* | 1.589 (1.189-2.124) | 0.002* |
| Laparoscopic surgery | 0.888 (0.588-1.342) | 0.574 | 0.915 (0.605-1.386) | 0.676 | 0.878 (0.582-1.326) | 0.536 | 0.877 (0.580-1.325) | 0.533 |
| Combined resection | 1.257 (0.812-1.945) | 0.305 | 1.252 (0.809-1.936) | 0.313 | 1.219 (0.786-1.892) | 0.377 | 1.249 (0.808-1.932) | 0.317 |
| Postoperative complications | 0.358 | 0.333 | 0.335 | 0.315 | ||||
| Grade II/ No | 1.218 (0.863-1.719) | 0.262 | 1.221 (0.865-1.724) | 0.255 | 1.230 (0.872-1.735) | 0.239 | 1.231 (0.872-1.736) | 0.238 |
| Grade III-V/No | 1.349 (0.805-2.259) | 0.256 | 1.370 (0.818-2.293) | 0.231 | 1.352 (0.808-2.263) | 0.251 | 1.376 (0.819-2.309) | 0.228 |
| Adjuvant chemotherapy | 0.444 (0.326-0.603) | <0.001* | 0.436 (0.321-0.594) | <0.001* | 0.440 (0.323-0.599) | <0.001* | 0.444 (0.326-0.605) | <0.001* |
*Statistically significant (P < 0.05);
HR, hazard Ratio; CI, confidence interval; BMI, body mass index; ASA, American Society of Anesthesiologists; TNM, tumor-node-metastasis.