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Consanguinity Classification, According to the Model Described in This Study
| ROH interval, Mb | Froh, (%)∗ | Experimental offspring consanguinity classification |
|---|---|---|
| >123 | >4.6 | Consanguineous |
| 79–123 | 2.9–4-6 | Probably consanguineous |
| 22–79 | 0.8–2.9 | Uncertain |
| <22 | <0.8 | Nonconsanguineous |
Mb, megabase; ROH, run of homozygosity.
Froh is defined as the percentage of the genome that is homozygous compared with the total autosomal genomic length (approximately 2691 Mb for GRCh37/hg19).
