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. 2020 Mar 29;11(5):1126–1136. doi: 10.1111/jdi.13235

Figure 2.

Figure 2

Administration of rapamycin (Rapa) activated autophagy, inhibited domain‐like receptor protein 3 (NLRP3) inflammasome and finally alleviated myocardial after ischemia‐reperfusion injury (I/RI). (a,g) Western blot was used to analyze the expression of (b) LC3‐II/, (c) p62, (d) NLRP3, (e) apoptosis‐related spots protein (ASC), (f) caspase‐1 p20, (h) interleukin (IL)‐1β and (i) IL‐18. (j) Representative images of myocardial infarct size determined by tetrazolium/formazan test and Evans blue staining; post‐ischemic infarct size expressed as the percentage of infarct size (IS) to the area at risk (AAR). (k) Serum lactate dehydrogenase (LDH) level. (l) Serum creatine kinase myocardial band (CK‐MB) level. Data are shown as the mean ± standard error of the mean. *P < 0.05 versus control (Ctrl) sham; # P < 0.05 versus Ctrl sham I/R); @ P < 0.05 versus diabetes (DM) sham; $ P < 0.05 versus Ctrl I/RI + Rapa; & P < 0.05 versus DM I/RI; n = 6/group.