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. 2020 Sep 7;10:14693. doi: 10.1038/s41598-020-71531-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of 5-FU and Sim treatments on cardiac (A) content of p-ERK, (B) expression of ROCK, (C) expression and (D) activity of caspase-3 and (E) DNA fragmentation analysis, in which 5-FU group shows DNA laddering. Values are presented as the mean of 6–8 experiments ± SEM. Statistical analysis was carried out using one-way ANOVA followed by Tukey’s post-hoc test; as compared to normal (*), Sim (#), and 5-FU (@)-treated groups (p < 0.05). 5-FU 5-fluorouracil, M, marker DNA (1 kb), p-ERK1/2 (Thr202/Tyr204), phosphorylated extracellular signal-regulated kinase 1/2 at Thr 202 & Tyr 204, ROCK rho-kinase, Sim simvastatin.