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. 2020 Sep 7;10:14693. doi: 10.1038/s41598-020-71531-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Sim on 5-FU-induced histological changes in cardiomyocytes. Photomicrographs (A–D) represent specimens taken from the heart and changes are indicated in the panel by black arrows. Slides of (A) normal control group and (B) normal animals treated with Sim show unremarkable changes, while that from (C1) 5-FU group shows intermuscular inflammatory cells infiltration associated with edema. Additionally, (C2, C3) slides from 5-FU group show focal necrosis of cardiomyocytes associated with congestion of myocardial blood vessel, as well as vacuolization of the sarcoplasm of cardiomyocytes. However, slide from animals treated with (D) 5-FU + Sim shows no histopathological changes. 5-FU 5-flourouracil, Sim simvastatin (H&E × 400; scale bar: 20 µm).