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. 2020 Sep 7;10:14693. doi: 10.1038/s41598-020-71531-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Sim on 5-FU-induced histological changes in aortic tissue. Photomicrographs from a-d represent specimens taken from the aorta. Sections from (a) normal control group and that (b) treated with Sim, show normal histological layers with no histopathological changes. On the contrary, sections of (c1–c3) 5-FU treated animals show vacuolation of cells of tunica media, whereas section (d) from 5-FU + Sim group shows no histopathological changes. 5-FU 5-flourouracil; Sim simvastatin (H&E × 400; scale bar: 20 µm).