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. 2020 Sep 7;10:14700. doi: 10.1038/s41598-020-71626-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship in fundus autofluorescent spots, apoptosis of photoreceptors and retinal ONL thickness in the central retina of rd10 raised under regular light cycle. (A) Pictures show the time course change in the central retina of rd10 from P16 to P60. Left pictures are in vivo FAF imaging with a retinal imaging microscope. Middle pictures show the confocal images of extracted flat-mounted retina at the ONL level, labeled with an apoptosis marker ssDNA (white). Scale bars, 100 μm, “ + ” show the center of the optic nerve head. Right pictures show the retinal section labeled with DAPI (blue), ssDNA (white) and Iba1 (red). Scale bars, 50 μm. (B) The graphs show the quantification of the FAF spot area % (green line), the ssDNA⁺ area % (black line), the thickness of the ONL (blue line) and thinning rate of the ONL (magenta line). The markers of the graph show mean and SD (n = 4). The peak of thinning rate of the ONL and the peak of FAF spot area were observed synchronously on P22 with a slight delay after the peak of apoptosis.