Table 2. Postoperative pain score, intraoperative morphine and postoperative morphine consumption.
| Variables
n (%) or median [IQR] |
Placebo-Placebo
( n = 21) |
Nefopam-Placebo
( n = 22) |
Placebo-Nefopam
( n = 22) |
Nefopam-Nefopam
( n = 21) |
p-value |
|---|---|---|---|---|---|
| Pain score | |||||
| 0 hr | 1 [0-5] | 4 [0-5] | 1 [0-5] | 3 [0-5] | 0.989 |
| 4 hr | 5.5 [3-7.8] | 5 [4-6.5] | 5 [4-8] | 6 [5-7] | 0.856 |
| 8 hr | 5 [3-6] | 5 [4-6] | 4 [3.8-6] | 5 [4-6.5] | 0.686 |
| 12 hr | 5 [4.5-6] | 5 [3-5.5] | 5 [3-7] | 5 [3-6] | 0.732 |
| 16 hr | 5 [3.5-5.5] | 4 [3-5] | 4.5 [3-6.5] | 5 [3-6] | 0.469 |
| 20 hr | 4 [3-5] | 3.5 [3-5] | 3.5 [3-5] | 3 [3-5] | 0.963 |
| 24 hr | 4 [3-4.5] | 3 [2-4.25] | 3.5 [3-5] | 4 [3-5] | 0.647 |
| Intraoperative morphine (mg) | 12 [10-15] | 12.5 [10-15] | 14 [11.5-15] | 13 [10-14] | 0.498 |
| Morphine bolus (mg) | 0 | 0 [0-0.5] | 0 | 0 [0-2] | 0.236 |
| Morphine consumption (mg) | |||||
| 0 - 4 hr | 3 [1-11] | 5 [4-11] | 5 [2-6.5] | 3 [2-6.5] | 0.623 |
| 0 - 8 hr | 7 [4-16] | 9 [6.75-12.3] | 9 [3-9.5] | 6 [4.5-10] | 0.617 |
| 0 - 12 hr | 11 [6-21.5] | 12.5 [9-15.5] | 10 [5-15] | 9 [6-11.5] | 0.361 |
| 0 - 16 hr | 14 [8-26] | 15.5 [11-19.5] | 15 [6.5-21.5] | 10 [7-14.5] | 0.297 |
| 0 - 20 hr | 16 [12-28] | 19 [11-24.8] | 17 [9-25] | 12 [7.5-16] | 0.259 |
| 0 - 24 hr | 18 [13.5-29] | 20 [11-28.3] | 17 [11.5-28.5] | 13 [8.5-18.5] | 0.223 |