Table 2. Demographic details of the study participants.

	Patients ( n = 20)	Controls ( n = 7)
Gender a	12 males	5 males
Age (months) (Average, range)	16.8 (3-92)	8.5 (3-12)
SCORAD (Average, range)	47.2 (9.7-70.5)	n.a.
TEWL (Average, range) b, *	24.7 (9.4-43.1)	9.6 (4.0-13.1)
FLG status:     Wild-type     Heterozygous LOF mutation     Homozygous/compound heterozygous LOF mutations	5 10 5	5 2 0

^afor two AD patients no gender was noted

^b for one healthy control no TEWL was noted

*Difference between patients and healthy controls, P<0.01; n.a.: not applicable

TEWL: Transepidermal Water Loss

SCORAD: (SCORing Atopic Dermatitis) tool

LOF: Loss-of-function

FLG: filaggrin gene