Table 3. Top 50 up-regulated and down-regulated genes in the E19 fetal brain.
| E19 Brain | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Up-regulated (chronic/control) | Down-regulated (chronic/control) | Up-regulated (acute/control) | Down-regulated (acute/control) | |||||||||
| ID | Gene | FC | ID | Gene | FC | ID | Gene | FC | ID | Gene | FC | |
| 1 | NM_001258011 | Snhg11 | 3.41 | NM_053304 | Col1a1 | -10.15 | NM_001258011 | Snhg11 | 4.13 | NM_053304 | Col1a1 | -16.3 |
| 2 | NM_012959 | Gfra1 | 3.38 | NM_001003978 | Gspt1 | -9.21 | NM_001108951 | Ak5 | 3.57 | NM_032085 | Col3a1 | -6.99 |
| 3 | NM_001170531 | Rasgrf1 | 2.76 | NM_001365151 | Crmp1 | -7.56 | NM_012959 | Gfra1 | 3.43 | NM_001365151 | Crmp1 | -4.70 |
| 4 | NM_012920 | Camk2a | 2.57 | NM_032085 | Col3a1 | -6.98 | NM_012920 | Camk2a | 3.28 | NM_001008890 | Hbe1 | -3.37 |
| 5 | NR_037614 | Vof16 | 2.47 | NM_001013853 | Hba-a3 | -5.10 | NM_001109003 | Cpne4 | 3.09 | NM_033234 | Hbb | -3.26 |
| 6 | NM_001105878 | Polq | 2.30 | NM_057212 | Tmem158 | -4.86 | NM_012671 | Tgfa | 3.03 | NM_001127523 | Mis18a | -3.04 |
| 7 | NM_001105880 | Zbtb20 | 2.28 | NM_130829 | Palm | -4.70 | NM_012519 | Camk2d | 2.94 | NM_001109627 | Epop | -3.02 |
| 8 | NR_131064 | RGD1566401 | 2.27 | NM_001025041 | Ier5l | -3.95 | NM_001170531 | Rasgrf1 | 2.80 | NM_001025041 | Ier5l | -3.01 |
| 9 | NM_001191970 | Thsd7a | 2.25 | NM_001191905 | Scrt2 | -3.83 | NM_001127492 | Sphkap | 2.73 | NM_001108464 | Prr18 | -2.90 |
| 10 | NM_001191752 | Ccdc77 | 2.20 | NM_001108599 | Scand1 | -3.72 | NM_001191970 | Thsd7a | 2.70 | NM_001111269 | Hbb-bs | -2.81 |
| 11 | NM_001107310 | Spock3 | 2.15 | NM_001108464 | Prr18 | -3.71 | NR_131064 | RGD1566401 | 2.60 | NM_001191905 | Scrt2 | -2.74 |
| 12 | NM_001172305 | Prkcb | 2.12 | NM_001109627 | Epop | -3.24 | NM_030993 | Ddn | 2.59 | NM_057212 | Tmem158 | -2.73 |
| 13 | NR_126581 | Lnc215 | 2.10 | NM_001109116 | Prr7 | -3.24 | NM_017318 | Ptk2b | 2.40 | NM_001108599 | Scand1 | -2.57 |
| 14 | NM_021853 | Kcnt1 | 2.06 | NM_001106014 | RGD1560394 | -3.10 | NM_001107671 | Plcxd3 | 2.40 | NM_001113223 | LOC100134871 | -2.57 |
| 15 | NM_001271191 | Sgo2 | 2.00 | NM_033234 | Hbb | -3.06 | NM_001108335 | Rasal1 | 2.36 | NM_001106299 | Ahsp | -2.57 |
| 16 | NM_053505 | Slc24a3 | 1.98 | NM_001111269 | Hbb-bs | -2.89 | NM_001105880 | Zbtb20 | 2.34 | NM_013197 | Alas2 | -2.57 |
| 17 | NM_206847 | Pfkp | 1.98 | NM_030862 | Marcksl1 | -2.62 | NM_001271404 | Hs6st3 | 2.34 | NR_027324 | H19 | -2.55 |
| 18 | NM_017007 | Gad1 | 1.98 | NM_001107307 | Cilp2 | -2.47 | NM_013192 | Kcnj6 | 2.32 | NM_030862 | Marcksl1 | -2.51 |
| 19 | NM_013192 | Kcnj6 | 1.97 | NM_001109270 | Fam110d | -2.46 | NM_001001508 | Plppr4 | 2.28 | NM_012651 | Slc4a1 | -2.38 |
| 20 | NM_053336 | Ager | 1.97 | NM_001008890 | Hbe1 | -2.46 | NM_021853 | Kcnt1 | 2.26 | NM_001109116 | Prr7 | -2.12 |
| 21 | NR_111959 | Miat | 1.96 | NR_027324 | H19 | -2.37 | NM_134363 | Slc12a5 | 2.23 | NM_001115013 | Selenom | -2.02 |
| 22 | NM_031003 | Abat | 1.94 | NM_001106066 | Pgls | -2.36 | NM_001289778 | Map7d2 | 2.20 | NM_181380 | Rtn4rl2 | -2.02 |
| 23 | NM_001136241 | Ngef | 1.91 | NM_001107745 | C1qtnf4 | -2.33 | NM_012713 | Prkcb | 2.19 | NM_001168650 | Sox12 | -1.99 |
| 24 | NM_012713 | Prkcb | 1.89 | NM_001113223 | LOC100134871 | -2.29 | NM_001191752 | Ccdc77 | 2.17 | NM_001106014 | RGD1560394 | -1.99 |
| 25 | NR_130129 | Tincr | 1.85 | NM_001168650 | Sox12 | -2.25 | NM_001134837 | Trps1 | 2.14 | NM_019291 | Car2 | -1.97 |
| 26 | NM_053817 | Nrxn3 | 1.83 | NM_013197 | Alas2 | -2.23 | NM_030871 | Pde1a | 2.13 | NM_001037659 | Mpp1 | -1.95 |
| 27 | NM_001202552 | Eif4ebp3 | 1.82 | NM_001037659 | Mpp1 | -2.21 | NM_053505 | Slc24a3 | 2.10 | NM_022300 | Basp1 | -1.93 |
| 28 | NM_001106895 | Tfap2d | 1.82 | NM_001164043 | Mapkapk5 | -2.20 | NM_001136241 | Ngef | 2.09 | NM_001107951 | Dmrta2 | -1.90 |
| 29 | NM_001014207 | Taf1d | 1.80 | NM_022300 | Basp1 | -2.17 | NM_017007 | Gad1 | 2.08 | NM_001106066 | Pgls | -1.90 |
| 30 | NM_024371 | Slc6a1 | 1.79 | NM_001109621 | Tpgs1 | -2.14 | NM_206847 | Pfkp | 2.07 | NM_031114 | S100a10 | -1.86 |
| 31 | NM_031783 | Nefl | 1.78 | NM_001107603 | Fbxl15 | -2.11 | NM_001135779 | Gabra2 | 2.04 | NM_001107307 | Cilp2 | -1.86 |
| 32 | NM_153630 | Nalcn | 1.75 | NM_181380 | Rtn4rl2 | -2.07 | NM_031003 | Abat | 2.04 | NM_001100741 | Col6a2 | -1.83 |
| 33 | NM_001271366 | Mki67 | 1.74 | NM_019386 | Tgm2 | -2.07 | NM_001172305 | Prkcb | 2.03 | NM_017271 | Nudc | -1.81 |
| 34 | NM_017275 | Pnck | 1.74 | NM_017271 | Nudc | -2.03 | NM_001108542 | Arhgef28 | 2.03 | NM_001109621 | Tpgs1 | -1.77 |
| 35 | NM_001107659 | Sema5a | 1.72 | NM_001071776 | Bola1 | -2.01 | NM_001025664 | Wsb1 | 1.98 | NM_001169138 | Thbs2 | -1.76 |
| 36 | NM_022631 | Wnt5a | 1.72 | NM_001130570 | Scrt1 | -2.00 | NM_001106895 | Tfap2d | 1.98 | NM_001164043 | Mapkapk5 | -1.76 |
| 37 | NM_001107638 | Scml4 | 1.72 | NM_001013163 | Bmyc | -2.00 | NM_173121 | Brinp3 | 1.98 | NM_001109270 | Fam110d | -1.76 |
| 38 | NM_031046 | Itpr2 | 1.71 | NM_001107951 | Dmrta2 | -2.00 | NM_001107310 | Spock3 | 1.98 | NM_001107745 | C1qtnf4 | -1.75 |
| 39 | NM_001029911 | Cit | 1.71 | NM_031677 | Fhl2 | -1.95 | NM_057130 | Hrk | 1.98 | NM_001195482 | Ndufaf8 | -1.73 |
| 40 | NM_031730 | Kcnd2 | 1.70 | NM_021678 | Camk2n2 | -1.95 | NM_001107473 | Zim1 | 1.97 | NM_001130570 | Scrt1 | -1.72 |
| 41 | NM_001012235 | Impact | 1.70 | NM_019291 | Car2 | -1.93 | NM_017275 | Pnck | 1.96 | NM_019354 | Ucp2 | -1.72 |
| 42 | NM_057130 | Hrk | 1.69 | NM_001134570 | Nupr2 | -1.93 | NM_001107881 | Plxnd1 | 1.95 | NM_031677 | Fhl2 | -1.71 |
| 43 | NM_001134553 | Ubn2 | 1.67 | NM_001195482 | Ndufaf8 | -1.93 | NM_177481 | Slco3a1 | 1.95 | NM_001025137 | Ier5 | -1.70 |
| 44 | NM_133302 | Adarb2 | 1.66 | NM_019326 | Neurod2 | -1.87 | NM_153630 | Nalcn | 1.93 | NM_001108955 | Fjx1 | -1.70 |
| 45 | NM_001107881 | Plxnd1 | 1.66 | NM_001106299 | Ahsp | -1.87 | NM_001271191 | Sgo2 | 1.93 | NM_019326 | Neurod2 | -1.70 |
| 46 | NM_052807 | Igf1r | 1.65 | NM_001107574 | Znhit2 | -1.87 | NM_001107659 | Sema5a | 1.92 | NM_001107603 | Fbxl15 | -1.69 |
| 47 | NM_001037139 | Pcdhga2 | 1.64 | NM_012651 | Slc4a1 | -1.86 | NM_001106498 | Pak6 | 1.91 | NM_001107708 | Olfml3 | -1.67 |
| 48 | NM_001107201 | Prox1 | 1.64 | NM_001127523 | Mis18a | -1.85 | NM_001114656 | Jmjd7 | 1.88 | NM_001134570 | Nupr2 | -1.67 |
| 49 | NM_001107281 | Klf12 | 1.64 | NM_012932 | Crmp1 | -1.84 | NM_001108242 | Slc9a7 | 1.87 | NM_031838 | Rps2 | -1.66 |
| 50 | NM_001107425 | Nfat5 | 1.63 | NM_001142652 | Neurl1b | -1.82 | NM_053817 | Nrxn3 | 1.87 | NM_019905 | Anxa2 | -1.66 |
Transcript numbers following chronic, acute or control maternal treatment with paracetamol, n=4 in each group. For details of dosage schedules see Methods. Data from RNA-Seq analysis. FC = fold change compared to control.