Table 4. Changes in gene regulation in E19 fetal brain following maternal treatment with paracetamol.
| E19 Brain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Up-regulated (chronic/control) | Up-regulated (acute/control) | ||||||||
| ID | Gene | Ch / Co | Ac / Co | Ch / Ac | ID | Gene | Ch / Co | Ac / Co | Ch / Ac |
| NM_053336 | Ager | 1.97 | - | - | NM_017318 | Ptk2b | - | 2.40 | - |
| NM_001202552 | Eif4ebp3 | 1.82 | - | - | NM_001004444 | Zbtb1 | - | 1.52 | - |
| NM_022631 | Wnt5a | 1.72 | - | - | NM_001108614 | Lime1 | - | 1.51 | - |
| NM_001105734 | Dusp10 | 1.54 | - | - | NM_001107770 | Sppl2a | - | 1.44 | - |
| NM_017187 | Hmgb2 | 1.47 | - | - | NM_001105733 | Cacnb4 | - | 1.31 | - |
| NM_001107678 | Dhx36 | - | 1.16 | - | |||||
| Down-regulated (chronic/control) | Down-regulated (acute/control) | ||||||||
| ID | Gene | Ch / Co | Ac / Co | Ch / Ac | ID | Gene | Ch / Co | Ac / Co | Ch / Ac |
| NM_001033968 | Bag6 | -1.52 | - | - | NM_030858 | Smad7 | - | -1.45 | - |
| NM_001100565 | Peli1 | -1.27 | - | - | NM_022701 | Flot1 | - | -1.20 | - |
| NM_001008322 | Shmt2 | -1.21 | - | - | NM_017278 | Psma1 | - | -1.17 | - |
| NM_133388 | Rbm14 | -1.19 | - | - | NM_001128083 | Trim8 | - | -1.16 | - |
| NM_138710 | Dab2ip | -1.18 | - | - | NM_001106332 | Otub1 | - | -1.16 | - |
| NM_001039914 | Akirin2 | -1.17 | - | - | NM_021655 | Chga | - | -1.14 | - |
| NM_012752 | Cd24 | -1.15 | - | - | |||||
Up-regulated and down-regulated inflammatory and immune-related gene changes in the E19 fetal brain following no treatment (Co, controls), acute (Ac,) or chronic (Ch) maternal paracetamol treatment; see Methods for details of dosage schedule. Data from RNA-Seq analysis. Numbers are fold changes for comparisons indicated (Ch/Co, Ac/Co; Ch/Ac). Compared to the placenta, in the fetal brain many fewer inflammatory and immune-related genes showed regulatory changes and there were no significant differences between acute and chronic treatments. - indicates no significant difference in fold changes, not that there was no fold change.