Table 5. Inflammatory and immune-related gene regulation in both acute and chronic treatment with paracetamol.
| E19 Placenta | E19 Brain | ||||||
|---|---|---|---|---|---|---|---|
| Up-regulated (chronic/control & acute/control) | Up-regulated (chronic/control & acute/control) | ||||||
| ID | Gene | Ch / Co | Ac / Co | ID | Gene | Ch / Co | Ac / Co |
| NM_001009623 | Tnfsf13 | 2.09 | 2.07 | NM_001172305 | Prkcb | 2.12 | 2.03 |
| NM_001034010 | Tril | 1.63 | 1.79 | NM_012713 | Prkcb | 1.89 | 2.19 |
| NM_001033691 | Irf7 | 1.92 | 1.52 | NM_052807 | Igf1r | 1.65 | 1.49 |
| NM_017269 | Ptprj | 1.70 | 1.52 | NM_053374 | Il18bp | 1.60 | 1.52 |
| NM_001106123 | Mrc1 | 1.64 | 1.45 | NM_001106757 | Cfp | 1.57 | 1.53 |
| NM_019211 | Rasgrp1 | 1.45 | 1.41 | NM_001276715 | Prkd1 | 1.39 | 1.41 |
| NM_001008886 | RT1-S3 | 1.31 | 1.40 | NM_001079894 | Plekha1 | 1.37 | 1.48 |
| NM_019140 | Ptprs | 1.31 | 1.40 | NM_001106095 | Lig4 | 1.33 | 1.33 |
| NM_012512 | B2m | 1.37 | 1.37 | NM_013187 | Plcg1 | 1.26 | 1.24 |
| NM_019195 | Cd47 | 1.24 | 1.34 | NM_012747 | Stat3 | 1.24 | 1.25 |
| NM_133395 | Serinc5 | 1.26 | 1.29 | ||||
| NM_052807 | Igf1r | 1.26 | 1.26 | ||||
| Down-regulated (chronic/control & acute/control) | Down-regulated (chronic/control & acute/control) | ||||||
| ID | Gene | Ch / Co | Ac / Co | ID | Gene | Ch / Co | Ac / Co |
| NM_012738 | Apoa1 | -451.9 | -15.74 | NM_032085 | Col3a1 | -6.98 | -6.99 |
| NM_022924 | F2 | -76.52 | -15.32 | NM_001109116 | Prr7 | -3.24 | -2.12 |
| NM_012737 | Apoa4 | -17.35 | -7.72 | NM_030826 | Gpx1 | -1.67 | -1.52 |
| NM_017097 | Ctsc | -6.06 | -6.18 | NM_030859 | Mdk | -1.33 | -1.39 |
| NM_133393 | Lfng | -4.30 | -3.26 | NM_053761 | Zyx | -1.33 | -1.39 |
| NM_001109116 | Prr7 | -2.14 | -2.99 | NM_212509 | Nfkbil1 | -1.43 | -1.38 |
| NM_024160 | Cyba | -2.03 | -2.49 | NM_022257 | Masp1 | -1.44 | -1.38 |
| NM_033351 | Fcgrt | -1.85 | -1.68 | NM_001277283 | Irak1bp1 | -1.32 | -1.36 |
| NM_001135922 | Ttll12 | -1.41 | -1.54 | NM_001134974 | Trim27 | -1.40 | -1.35 |
| NM_001006969 | Irf3 | -1.56 | -1.50 | NM_022546 | Dapk3 | -1.58 | -1.35 |
| NM_133293 | Gata3 | -1.53 | -1.42 | NM_001106164 | Cmtm3 | -1.40 | -1.35 |
| NM_001106446 | Zbtb7b | -1.33 | -1.32 | NM_001108153 | Sema7a | -1.38 | -1.33 |
| NM_001025136 | Hexim1 | -1.34 | -1.24 | NM_172045 | Ppp1r14b | -1.36 | -1.32 |
| NM_130411 | Coro1a | -1.41 | -1.31 | ||||
| NM_053669 | Sh2b2 | -1.32 | -1.31 | ||||
| NM_001004080 | Gsn | -1.35 | -1.30 | ||||
| NM_053727 | Nfil3 | -1.21 | -1.29 | ||||
| NM_012931 | Bcar1 | -1.25 | -1.24 | ||||
| NM_001107063 | Cdc42ep4 | -1.26 | -1.23 | ||||
| NM_031629 | Psmb4 | -1.26 | -1.20 | ||||
| NM_019259 | C1qbp | -1.20 | -1.20 | ||||
| NM_001031653 | Polr3d | -1.17 | -1.19 | ||||
| NM_053743 | Cdc37 | -1.23 | -1.19 | ||||
| NM_001047099 | Ythdf2 | -1.18 | -1.19 | ||||
Only genes that showed a response in placentas from E19 animals (left panels) and fetal brains (right panels) following both acute and chronic maternal treatment with paracetamol are shown; see Methods for details of dosage schedule. Data from RNA-Seq analysis. Numbers are fold changes for comparisons indicated (Ch/Co, Ac/Co; Ch/Ac). There were no significant differences for these genes between acute and chronic treatments, although there were small fold changes (data not shown).