Table 1. Top 50 up-regulated and down-regulated genes in the E19 placenta following treatment with paracetamol.
| E19 Placenta | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Up-regulated (acute/control) | Down-regulated (acute/control) | Up-regulated (chronic/control) | Down-regulated (chronic/control) | |||||||||||||
| ID | Gene | FC | ID | Gene | FC | ID | Gene | FC | ID | Gene | FC | |||||
| 1 | NM_031582 | Aoc3 | 4.68 | NM_201419 | Clca4 | -54 | NM_013025 | Ccl3 | 42 | NM_012493 | Afp | -2332 | ||||
| 2 | NM_001105894 | Chodl | 3.98 | NM_012493 | Afp | -18 | NM_053647 | Cxcl2 | 23 | NM_001085352 | Apoc2 | -1698 | ||||
| 3 | NM_001164726 | Fcrl6 | 3.84 | NM_012559 | Fgg | -18 | NM_031512 | Il1b | 13 | NM_013162 | Rbp4 | -1415 | ||||
| 4 | NM_001106063 | LOC290595 | 3.45 | NM_019373 | Apom | -18 | NM_022194 | Il1rn | 7.75 | NM_019287 | Apob | -900 | ||||
| 5 | NM_001317798 | LOC684107 | 3.37 | NM_001085352 | Apoc2 | -16 | NM_019282 | Grem1 | 5.62 | NM_020071 | Fgb | -639 | ||||
| 6 | NM_001191752 | Ccdc77 | 2.95 | NM_053577 | Spp2 | -16 | NM_130741 | Lcn2 | 3.89 | NM_013112 | Apoa2 | -474 | ||||
| 7 | NM_199233 | Doxl1 | 2.84 | NM_012738 | Apoa1 | -16 | NM_001131001 | Fcer1g | 3.20 | NM_012738 | Apoa1 | -452 | ||||
| 8 | NM_001107071 | Cbx2 | 2.66 | NM_022924 | F2 | -15 | NM_001317798 | LOC684107 | 3.12 | NM_012681 | Ttr | -356 | ||||
| 9 | NM_181378 | Ctsm | 2.57 | NM_001013110 | Tf | -14 | NM_001025750 | Plek | 2.99 | NM_012559 | Fgg | -278 | ||||
| 10 | NM_001109120 | Mboat1 | 2.44 | NM_001107727 | Mttp | -12 | NM_024145 | Fgr | 2.87 | NM_053577 | Spp2 | -249 | ||||
| 11 | NM_031545 | Nppb | 2.40 | NM_022519 | Serpina1 | -12 | NM_012711 | Itgam | 2.86 | NM_022519 | Serpina1 | -236 | ||||
| 12 | NM_022846 | Prl8a2 | 2.36 | NM_013198 | Maob | -10 | NM_001007694 | Ifit3 | 2.77 | NM_201419 | Clca4 | -166 | ||||
| 13 | NM_144744 | Adipoq | 2.35 | NM_001100690 | Myh14 | -8.80 | NM_012523 | Cd53 | 2.77 | NM_019373 | Apom | -162 | ||||
| 14 | NM_001329892 | LOC102557319 | 2.31 | NM_134432 | Agt | -8.78 | NM_017133 | Thbs4 | 2.77 | NM_022924 | F2 | -77 | ||||
| 15 | NM_021580 | Prl8a4 | 2.28 | NM_012737 | Apoa4 | -7.72 | NM_021744 | Cd14 | 2.71 | NM_001013110 | Tf | -57 | ||||
| 16 | NM_001101007 | LOC683313 | 2.27 | NM_013170 | Gucy2c | -7.72 | NM_130426 | Tnfrsf1b | 2.51 | NM_001107727 | Mttp | -43 | ||||
| 17 | NM_001025679 | Psg16 | 2.27 | NM_053332 | Cubn | -7.69 | NM_001122776 | Kcnc4 | 2.50 | NM_053332 | Cubn | -28 | ||||
| 18 | NM_022176 | Prl6a1 | 2.25 | NM_017097 | Ctsc | -6.18 | NM_031545 | Nppb | 2.36 | NM_012737 | Apoa4 | -17 | ||||
| 19 | NM_001245978 | Frem2 | 2.22 | NM_019158 | Aqp8 | -5.24 | NM_001105720 | Nfkbia | 2.33 | NM_013170 | Gucy2c | -17 | ||||
| 20 | NM_022667 | Slco2a1 | 2.21 | NM_001108061 | Amn | -4.59 | NM_001107830 | Lamc3 | 2.33 | NM_013198 | Maob | -16 | ||||
| 21 | NM_022198 | Clcn4 | 2.17 | NM_001106846 | Cldn2 | -3.52 | NM_001100827 | Cenpf | 2.27 | NM_001100690 | Myh14 | -15 | ||||
| 22 | NM_001025641 | Psg29 | 2.09 | NM_001134516 | Uap1l1 | -3.52 | NM_053822 | S100a8 | 2.26 | NM_134432 | Agt | -14 | ||||
| 23 | NM_001009623 | Tnfsf13 | 2.07 | NM_001108224 | Vil1 | -3.34 | NM_020100 | Ramp3 | 2.25 | NM_001108061 | Amn | -6.89 | ||||
| 24 | NM_017036 | Prl4a1 | 2.03 | NM_012511 | Atp7b | -3.29 | NM_030845 | Cxcl1 | 2.21 | NM_001170403 | Orai2 | -6.36 | ||||
| 25 | NM_001122776 | Kcnc4 | 2.03 | NM_133393 | Lfng | -3.26 | NM_057210 | Sv2a | 2.17 | NM_017097 | Ctsc | -6.06 | ||||
| 26 | NM_031521 | Ncam1 | 1.98 | NM_031620 | Lfng | -3.11 | NM_001191752 | Ccdc77 | 2.17 | NM_130829 | Palm | -5.39 | ||||
| 27 | NM_001012072 | Ppp1r3c | 1.97 | NM_001109116 | Prr7 | -2.99 | NM_001031642 | Serpinb1a | 2.17 | NM_133393 | Lfng | -4.30 | ||||
| 28 | NM_130779 | Adcy3 | 1.96 | NM_053802 | Tgfbi | -2.89 | NM_013175 | Scg5 | 2.17 | NM_001012115 | Creb3l3 | -4.18 | ||||
| 29 | NM_001127635 | Zfp9 | 1.95 | NM_001025002 | LOC310926 | -2.82 | NM_053587 | S100a9 | 2.16 | NM_001106846 | Cldn2 | -3.77 | ||||
| 30 | NM_001191862 | Flnc | 1.95 | NM_022533 | Pllp | -2.82 | NM_022198 | Clcn4 | 2.14 | NM_001134516 | Uap1l1 | -3.50 | ||||
| 31 | NM_017080 | Hsd11b1 | 1.94 | NM_001108178 | Pls1 | -2.71 | NM_001009623 | Tnfsf13 | 2.09 | NM_019158 | Aqp8 | -3.40 | ||||
| 32 | NM_001015011 | Il17f | 1.94 | NM_030862 | Marcksl1 | -2.71 | NM_001008384 | Rac2 | 2.07 | NR_131064 | RGD1566401 | -3.35 | ||||
| 33 | NM_017333 | Ednrb | 1.91 | NM_001108599 | Scand1 | -2.59 | NM_212525 | Tyrobp | 2.07 | NM_031620 | Phgdh | -3.29 | ||||
| 34 | NM_001100827 | Cenpf | 1.91 | NM_139192 | Scd | -2.56 | NM_001011954 | Cybrd1 | 2.03 | NM_001037210 | Gipc2 | -3.12 | ||||
| 35 | NM_001191918 | C1qtnf2 | 1.89 | NM_024160 | Cyba | -2.49 | NM_017080 | Hsd11b1 | 1.97 | NM_001014193 | Rsrp1 | -3.07 | ||||
| 36 | NM_031022 | Cspg4 | 1.88 | NR_131064 | RGD1566401 | -2.48 | NM_022954 | Fat2 | 1.97 | NM_001025002 | LOC310926 | -3.03 | ||||
| 37 | NM_017198 | Pak1 | 1.87 | NM_012862 | Mgp | -2.47 | NM_017051 | Sod2 | 1.96 | NM_139192 | Scd | -3.03 | ||||
| 38 | NM_172073 | Tpbpa | 1.85 | NM_001109627 | Epop | -2.47 | NM_001009681 | Oasl | 1.95 | NM_022533 | Pllp | -2.74 | ||||
| 39 | NM_001191915 | Gpr50 | 1.85 | NM_001014193 | Rsrp1 | -2.46 | NM_130779 | Adcy3 | 1.92 | NM_139087 | Cgref1 | -2.64 | ||||
| 40 | NM_001034010 | Tril | 1.79 | NM_177927 | Serpinf1 | -2.45 | NM_001033691 | Irf7 | 1.92 | NM_001108178 | Pls1 | -2.63 | ||||
| 41 | NM_134385 | Prl8a9 | 1.79 | NM_053565 | Socs3 | -2.45 | NM_001107887 | Cd163 | 1.92 | NM_001047891 | RGD1310507 | -2.63 | ||||
| 42 | NM_053360 | Sh3kbp1 | 1.78 | NM_001108971 | Myorg | -2.38 | NM_133624 | Gbp2 | 1.91 | NM_177927 | Serpinf1 | -2.61 | ||||
| 43 | NM_030994 | Itga1 | 1.78 | NM_001170584 | Pex5 | -2.31 | NM_012924 | Cd44 | 1.89 | NM_153736 | Prl3a1 | -2.56 | ||||
| 44 | NM_001109141 | Kctd15 | 1.76 | NM_139087 | Cgref1 | -2.31 | NM_001007691 | Prss23 | 1.87 | NM_001008890 | Hbe1 | -2.51 | ||||
| 45 | NM_001135877 | Taf7l | 1.76 | NM_001037210 | Gipc2 | -2.22 | NM_031764 | Ddr2 | 1.85 | NM_030827 | Lrp2 | -2.47 | ||||
| 46 | NM_001106515 | Fermt1 | 1.75 | NM_001191974 | Chst13 | -2.20 | NM_001134858 | Synm | 1.85 | NM_172030 | Entpd2 | -2.29 | ||||
| 47 | NM_001100984 | Ncf2 | 1.75 | NM_001037659 | Mpp1 | -2.17 | NM_001106420 | Adamts12 | 1.83 | NM_001109627 | Epop | -2.27 | ||||
| 48 | NM_001034932 | C1qtnf6 | 1.72 | NM_001108552 | Trim2 | -2.16 | NM_031022 | Cspg4 | 1.83 | NM_001014790 | Rarres1 | -2.26 | ||||
| 49 | NM_001271283 | Golm2 | 1.72 | NM_001012470 | Irf2bpl | -2.14 | NM_207606 | Kirrel1 | 1.83 | NM_019231 | Mapk13 | -2.24 | ||||
| 50 | NM_001106402 | Lhfpl2 | 1.71 | NM_001107052 | Arl4d | -2.11 | NM_019341 | Rgs5 | 1.82 | NM_001014088 | Eepd1 | -2.22 | ||||
Fold change of transcript numbers in placentas treated with paracetamol (chronic, acute or control, n=4 in each group). For details of dosage schedules see Methods. Data from RNA-Seq analysis. FC = fold change compared to control (p<0.05, see Methods). Colours indicate genes that were upregulated (green) in both acute and chronic treated animals and downregulated (red) in both acute and chronic treated animals. Note that only 10/50 genes were upregulated following both treatments but 34/50 were downregulated following both treatments.