. Author manuscript; available in PMC: 2020 Sep 8.

Published in final edited form as: Endocr Pathol. 2019 Jun;30(2):155–162. doi: 10.1007/s12022-019-9574-7

Table 1.

Comparison of NIFTP diagnostic criteria before and after proposed revisions

	Original diagnostic criteria¹⁰	Revised diagnostic criteria¹⁹
Encapsulation or clear demarcation
	X	X
Follicular growth pattern	X	X
< 1% papillary structures	X
No well-formed papillae	X	X
Nuclear features of PTC	X	X
No psammoma bodies	X	X
Nuclear features	X	X
Score 2–3	X	X
Nuclear elongation/grooves/chromatin clearing	X	X
< 30% solid/trabecular/insular growth pattern	X	X
No vascular and capsular invasion	X	X
No tumor necrosis	X	X
No high mitotic activity	X	X
Lack of BRAF^V600E mutation with IHC or molecular testing	X	X
Lack of BRAF-like mutations or other high-risk mutations (TERT and TP53)	X	X

PTC, papillary thyroid carcinoma; IHC, immunohistochemistry; X, inclusion criteria

Partially adapted from a table by Rossi ED and Faquin WC in Cancer Cytopathology 2018 [41]