eTable 3. Matrix of the recommendations for psychotherapeutic and psychosocial treatment procedures, with selected underlying source publications, relevant statistical measures, and recommendation grades.
| Positive symptoms | Prevention of relapse | Negative symptoms | Cognitive performance | Social functioning level | General symptoms | |||||||
| Psychoeducation | A | LoE1+ (e13) | ||||||||||
| NNT: 9 [7; 14] | ||||||||||||
| CBT (FEP) | A | LoE1– (e14) | n.d. | LoE1− (e14) | A | LoE1− (e14) | ||||||
| SMD; –0.60 [–0.79; –0.41] | RR = 0.67 [0.24; 1.85] | SMD −0.45 [−0.89; −0.09] | ||||||||||
| CBT (REC) | A | LoE1++ (e15) | A | LoE1++ (e15) | n.d. | LoE1++ (e15) | ||||||
| d = 0.372 [0.228; 0.516] | d = 0.437 [0.171; 0.704] | d = 0.378 [0.154; 0.602] | ||||||||||
|
Metacognitive training |
B | LoE1+ (e16) | ||||||||||
| g = −0.34 [−0.53; −0.15] | ||||||||||||
|
Family interventions |
A | LoE1− (20, e14) | ||||||||||
| RR = 0.58 [0.25; 1.36] | ||||||||||||
|
Systemic therapy |
0 | LoE1− (e17) | ||||||||||
| g = 0.69 [0.39; 0.99] | ||||||||||||
|
Social competence training |
A | LoE1++ (e18) | A | LoE1++ (e18) | ||||||||
| g = 0.218 [0.077; 0.359] | g = 0.252 [0.075; 0.428] | |||||||||||
|
Psychodynamic psychotherapy |
0 | LoE2+ (e19) | ||||||||||
| 6.42 [1.22; 11.61] | ||||||||||||
|
Cognitive remediation |
A | LoE1+ (e20) | A | LoE1+ (e20) | ||||||||
| d = 0.448 [0.306; 0.590] | d = 0.418 [0.216; 0.620] | |||||||||||
|
Supportive treatment |
0 | GA (20) | ||||||||||
| Ergotherapy | 0 | GA (e21) | ||||||||||
|
Art/music therapy |
B | GA (e21) | ||||||||||
| Physical therapy/sport | B | GA (e21) | ||||||||||
CBT, cognitive behavioral therapy; FEP, first-episode psychosis; GA, guideline adaptation; LoE, level of evidence; n.d., no data; REC, relapse
A: recommendation grade A; B: recommendation grade B, 0: recommendation grade 0
The superscripts after LoE show the evidence grade according to SIGN