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. 2020 Jul 8;142(10):101001. doi: 10.1115/1.4047076

Fig. 3.

Migration displacement and persistence, potential measures of breast cancer cell invasiveness, increase under shear but only for MDA-MB-231 cells. (a) Sheared MDA-MB-231 cells migrated significantly farther than MDA-MB-468 and MCF-10A cells. Interestingly, this was not likely due to an increased path efficiency (b) because there was little difference in confinement ratio. (c) MDA-MB-231 cells had greater persistence in migration (or lower arrest) in both static and sheared conditions compared with MDA-MB-468 and MCF-10A cells. Application of shear further decreased the arrest coefficient of MDA-MB-231 cells causing more persistent migration. #: comparison with MCF-10A static. ψ: comparison with MCF-10A FF15. *: comparison with MDA-MB-468 static. ‡: comparison with MDA-MB-468 FF15. Other comparisons did not reach statistical significance. Single, double, and triple symbols represent p < 0.05, p < 0.01, and p < 0.001, respectively.

Migration displacement and persistence, potential measures of breast cancer cell invasiveness, increase under shear but only for MDA-MB-231 cells. (a) Sheared MDA-MB-231 cells migrated significantly farther than MDA-MB-468 and MCF-10A cells. Interestingly, this was not likely due to an increased path efficiency (b) because there was little difference in confinement ratio. (c) MDA-MB-231 cells had greater persistence in migration (or lower arrest) in both static and sheared conditions compared with MDA-MB-468 and MCF-10A cells. Application of shear further decreased the arrest coefficient of MDA-MB-231 cells causing more persistent migration. #: comparison with MCF-10A static. ψ: comparison with MCF-10A FF15. *: comparison with MDA-MB-468 static. ‡: comparison with MDA-MB-468 FF15. Other comparisons did not reach statistical significance. Single, double, and triple symbols represent p < 0.05, p < 0.01, and p < 0.001, respectively.