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. Author manuscript; available in PMC: 2020 Sep 8.
Published in final edited form as: Acta Neuropathol. 2019 Sep 28;139(1):193–209. doi: 10.1007/s00401-019-02078-w

Table 2.

Report format for the diagnosis of isomorphic diffuse glioma. Molecular data in brackets are optional.

Layer Report format for integrated diagnosis – 2014 ISN-Haarlem guidelines [33] Report format for isomorphic diffuse glioma Example
1 Integrated diagnosis (incorporating all tissue-based information) Isomorphic diffuse glioma, [DNA methylation group isomorphic diffuse glioma MYBL1/MYB,*] [MYBL1/MYB- rearrangement,] [MYBL1/MYB fusion,] WHO grade not assigned (WHO grade I proposed) Isomorphic diffuse glioma, DNA methylation group isomorphic diffuse glioma MYBL1/MYB, MYBL1-rearrangement, MYBL1-MMP16 fusion, WHO grade not assigned (WHO grade I proposed)
2 Histological classification Diffuse glioma with low proliferation Diffuse glioma with low proliferation
3 WHO grade not assigned (WHO grade I proposed) not assigned (WHO grade I proposed)
4 Molecular information [DNA methylation group isomorphic diffuse glioma MYBL1/MYB, *] [MYBL1/MYB-rearrangement,] [MYBL1/MYB fusion] DNA methylation group isomorphic diffuse glioma MYBL1/MYB, MYBL1-rearrangement, MYBL1-MMP16 fusion
*

highly recommended.