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. 2020 Aug 25;8:516. doi: 10.3389/fped.2020.00516

Table 2.

Factors that contribute to ductal constriction after birth.

High levels of oxygen
Low levels of circulating prostaglandins
Increase in endothelin-1
Activation of cytochrome P450
Rise in intracellular calcium
Decrease in intracellular cAMP and cGMP
Inhibition of potassium channels
Production of isoprostanes
Response to acethycholine
Response to norepinephrine
Activation of transient receptor potential channels
Activation of Rho-kinase family members
Release of angiotensin II