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. 2020 Jul 2;12:85. doi: 10.1186/s13148-020-00877-7

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Methylation gains at immune response genes in stratified cases. a Principal component analysis (PCA) for all methylated sites of the 32 samples from subjects showing comorbid depression, self-harm and suicidal attempt compared to healthy controls. This indicated clear separation by gender, but also between cases (orange) and controls (green) for females. b Scatterplot of differential methylation, with the top 1000 probes in red. c Gene ontology analysis of the top differentially methylated gene bodies shows significant enrichment for immune system response terms. d Reanalysis of array data using an in-house Galaxy workflow. Differentially methylated probes whose coordinates matched genes from the top two ranks in c (relating to immune system response) were identified. Median methylation levels were assessed and again showed a significant difference between cases and controls (**p < 0.01)