Fig. 7.

Mutation-induced alterations of ABCG2 interaction with different types of inhibitors. The efflux of mitoxantrone by HEK293 cells expressing either wild-type ABCG2 (circles) or the S353A mutant (triangles) was measured by flow cytometry as in Fig. 4. Its inhibition by increasing concentrations of Ko143 (a), chromone 1 (b) or nilotinib (c) was plotted as indicated