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. Author manuscript; available in PMC: 2020 Sep 8.
Published in final edited form as: Structure. 2019 Jun 20;27(8):1286–1295.e4. doi: 10.1016/j.str.2019.05.010

Figure 6. Epitope Mapping of HVEM.

Figure 6.

(A) Epitope mapping results of human HVEM, The relative binding affinities are represented by the values when normalized to the wild-type HVEM binding affinity (standard deviations are results of triplicates). N.D. stands for no detectable binding. The residues are categorized as sensitive residues when more than 20% binding affinity was lost. These affected residue’s are highlighted by color. Two residues with more than 2-fold increased affinities are colored blue.

(B) Structural representation of the CD160:HVEM epitope mapping results. The HVEM residues subjected to epitope mapping are shown as sticks. The sensitive residues with more than 20% compromised binding are highlighted by purple color. CD160 is shown as gray surface.