Figure 2.

Mouse wounds. (A) Wound morphology. The Control and Diabetic control groups were contracting at a faster rate and healed by day 21. The Chronic diabetic group showed signs of necrosis on the wound border as well as signs of exudate and biofilm formation. The scaffold did not engraft well in any of the Treated chronic diabetic wounds. (B) Wound contraction. The wound areas were traced and analyzed using Image J. Both the Chronic diabetic and the Treated chronic diabetic wounds showed delayed healing when compared with the Control and Diabetic control mice with the difference between Diabetic control and Treated chronic diabetic being statistically significant (p<0.001). The wounds in both the Chronic diabetic and the Treated chronic diabetic groups became chronic and the Chronic diabetic did not heal for as long as 28 days. Scale bar is 1 cm. *p<0.05, **p<0.01, ***p<0.001.