Table 1.
Core characteristics of included studies
| Study | Region (country) | Study design (cohort) | Population at risk | Year of enrolment | Age (years) | Male sex (%) | Body mass index | Follow-up (years) | Study outcomes |
|---|---|---|---|---|---|---|---|---|---|
| Selmer 199214 | Europe (Norway) | Prospective | 9827 | 1963 to 1964 | 35 | 43.0 | 25.3 | 20 | CV events, CHD, stroke, and all cause mortality |
| Glasgow Alumni 200017 | Europe (UK) | Prospective | 8345 | 1948 to 1968 | 20.5 | 100 | 21.7 | 41.3 | CV events, CHD, stroke, and all cause mortality |
| CHA 200123 | North America (US) | Prospective | 10 874 | 1967 to 1973 | 29.7 | 100 | 26 | 25 | CV events, CHD, and all cause mortality |
| Strandberg 200113 | Europe(Finland) | Prospective | 3490 | 1964 to 1973 | 37.5 | 100 | 25.9 | 27 | CV events and all cause mortality |
| MRFIT 200222 | North America (US) | Prospective | 148 204 | 1973 to 1975 | 40 | 100 | 27.7 | 22 | CV events |
| Falkstedt 200816 | Europe (Sweden) | Prospective | 47 873 | 1969 to 1970 | 19 | 100 | 21 | 18 | CHD and stroke |
| Sauvaget 201021 | Asia (India) | Prospective | 62 435 | 1996 to 2004 | 40 | 38.4 | 21.3 | 7 | CV events, CHD, and stroke |
| HAHS 201115 | North America (US) | Prospective | 18 881 | 1962 to 1966 | 18.3 | 100 | 21.7 | 56.3 | CV events, CHD, stroke, and all cause mortality |
| Sundström 201110 | Europe (Sweden) | Prospective | 1 207 141 | 1969 to 1995 | 18.4 | 100 | 21.7 | 24 | CV events and all cause mortality |
| CARDIA 20189 | North America (US) | Prospective | 4851 | 1985 to 1986 | 35.7 | 45.2 | 27.7 | 18.8 | CV events, CHD, stroke, and all cause mortality |
| CMCS 201820 | Asia (China) | Prospective | 8551 | 1992 to 1993 | 39.3 | 47.0 | 24.2 | 13.7 | CV events, CHD, and stroke |
| KNHI 20188 | Asia (Korea) | Retrospective | 2 488 101 | 2002 to 2005 | 31 | 68.3 | 23.1 | 10 | CV events, CHD, and stroke |
| EPOCH-JAPAN 201918 | Asia (Japan) | Prospective | 107 737 | 1980 to 2002 | 35 | 42.4 | 23.1 | 15.2 | CV events, CHD, and stroke |
| Jee 201924 | Asia (Korea) | Retrospective | 118 531 | 1992 to 1994 | 26.7 | 100 | 22.3 | 23 | CV events, CHD, and stroke |
| Kim 201919 | Asia (Korea) | Retrospective | 232 349 | 2011 to 2016 | 39 | 54.0 | 23.2 | 4.3 | CV events, CHD, and stroke |
| Liu 201911 | Asia (China) | Prospective | 20 072 | 2004 to 2006 | 41.5 | 49.9 | 24.1 | 12.5 | CV events, CHD, stroke, and all cause mortality |
| Zhang 201912 | North America (US) | Prospective | 36 030 | 1971 to 2002 | 30 | 44.5 | 26.8 | 17 | CV events, CHD, and stroke |
CHD=coronary heart disease; CV=cardiovascular.