Table 1. Identification of differentially expressed proteins in BEAS-2B cells treated with CdTe QDs for 24 h. Protein spots were quantified after 2-D PAGE and identified by MS and protein database matching. The up- or down-regulation of proteins as compared with the untreated control is indicated by arrows.

Sample number	Abbreviation	Protein name	Accession no.	pI	MW (kDa)	Matched peptides	Coverage (%)	Mascot score
1	MYL12A	Myosin regulatory light chain 12A ↑	P19105	4.67	19.8	7	40.4	679
2	EIF5A	Eukaryotic translation initiation factor 5A-1 ↑	P63241	5.07	16.8	5	25.0	187
3	PRDX6	Peroxiredoxin-6 ↑	P30041	6.00	25.0	13	53.1	602
4	HSPB1	Heat shock protein beta-1 ↑	P04792	5.98	22.8	11	48.3	1947
5	RPLP0	60S acidic ribosomal protein P0 ↑	P05388	5.72	34.3	19	60.6	2294
6	PAFAH1B3	Platelet-activating factor acetylhydrolase IB subunit gamma ↑	Q15102	6.33	25.7	1	7.4	42
7	PA2G4	Proliferation-associated protein 2G4 ↑	Q9UQ80	6.13	43.8	25	49.2	4620
8	GSTP1	Glutathione S-transferase P ↑	P09211	5.43	23.4	12	61.0	1121
9	PPIA	Peptidyl-prolyl cis–trans isomerase A ↑	P62937	7.68	18.0	14	53.9	1608
10	EEF1B2	Elongation factor 1-beta ↑	P24534	4.5	24.8	7	35.1	887
11	TPT1	Translationally controlled tumor protein ↑	P13693	4.84	19.6	10	40.7	284
12	MYL12A	Myosin regulatory light chain 12A ↑	P19105	4.67	19.8	4	24.6	55
13	GSTP1	Glutathione S-transferase P ↑	P09211	5.43	23.4	1	7.6	35
14	ANXA1	Annexin A1 ↑	P04083	6.57	38.7	21	56.1	2062
15	NME1	Nucleoside diphosphate kinase A ↑	P15531	5.83	17.1	10	53.3	596
16	PARK7	Protein/nucleic acid deglycase DJ-1 ↑	Q99497	6.33	19.9	12	54.5	219
17	PRDX1	Peroxiredoxin-1 ↑	Q06830	8.27	22.1	15	53.3	1008
18	PPA1	Inorganic pyrophosphatase ↑	Q15181	5.54	32.7	11	35.3	368
19	UCHL1	Ubiquitin carboxyl-terminal hydrolase isozyme L1 ↑	P09936	5.33	24.8	8	36.8	241
20	CAPG	Macrophage-capping protein ↑	P40121	5.82	38.5	9	20.4	743
21	BLVRB	Flavin reductase (NADPH) ↑	P30043	7.13	22.1	5	22.3	172
22	PRDX2	Peroxiredoxin-2 ↑	P32119	5.66	21.9	8	39.9	494
23	HSPA6	Heat shock 70 kDa protein 6 ↑	P17066	5.81	71.0	14	23.2	538
24	EZR	Ezrin ↑	P15311	5.94	69.4	23	32.9	1509
25	ARHGDIA	Rho GDP-dissociation inhibitor 1 ↑	P52565	5.03	23.2	9	31.9	686
26	NUDT5	ADP-sugar pyrophosphatase ↑	Q9UKK9	4.87	24.3	8	35.2	137
27	PFN1	Profilin-1 ↑	P07737	8.44	15.1	11	71.4	2452
28	GNB2L1	Guanine nucleotide-binding protein subunit beta-2-like 1 ↑	P63244	7.6	35.1	13	39.1	2277
29	PPIA	Peptidyl-prolyl cis–trans isomerase A ↑	P62937	7.68	18.0	12	49.1	1197
30	PKM	Pyruvate kinase PKM ↑	P14618	7.96	57.9	13	26.0	359
31	IMPDH2	Inosine-5′-monophosphate dehydrogenase 2 ↓	P12268	6.44	55.8	21	33.1	1746
32	HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B ↓	Q99729	8.21	36.2	7	17.8	1088
33	DNAJB11	DnaJ homolog subfamily B member 11 ↓	Q9UBS4	5.81	40.5	5	17.9	185
34	LAP3	Cytosol aminopeptidase ↓	P28838	8.03	56.2	13	28.7	1084
35	MTHFD2	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial ↓	P13995	8.86	37.9	5	15.1	379
36	PSMB3	Proteasome subunit beta type-3 ↓	P49720	6.14	22.9	5	31.2	262
37	HNRNPL	Heterogeneous nuclear ribonucleoprotein L ↓	P14866	8.46	64.1	17	35.8	1542
38	ETFB	Electron transfer flavoprotein subunit beta ↓	P38117	8.25	27.8	13	51.4	642
39	TUFM	Elongation factor Tu, mitochondrial ↓	P49411	7.26	49.5	8	19.9	779
40	HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B ↓	Q99729	8.21	36.2	8	17.8	1737
41	HNRNPL	Heterogeneous nuclear ribonucleoprotein L ↓	P14866	8.46	64.1	25	45.2	3555
42	HSD17B10	3-Hydroxyacyl-CoA dehydrogenase type-2 ↓	Q99714	7.65	26.9	16	78.5	1576
43	PRDX3	Thioredoxin-dependent peroxide reductase, mitochondrial ↓	P30048	7.68	27.7	7	25.0	585
44	HADH	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial ↓	Q16836	8.88	34.3	6	15.3	174
45	PYCR1	Pyrroline-5-carboxylate reductase 1, mitochondrial ↓	P32322	7.18	33.4	2	7.5	176
46	PRDX4	Peroxiredoxin-4 ↓	Q13162	5.86	30.5	9	30.3	540
47	MRPL12	39S ribosomal protein L12, mitochondrial ↓	P52815	9.05	21.3	3	17.7	82
48	ATP5H	ATP synthase subunit d, mitochondrial ↓	O75947	5.21	18.5	9	47.8	307
49	PRDX3	Thioredoxin-dependent peroxide reductase, mitochondrial ↓	P30048	7.68	27.7	8	27.0	719
50	ERP29	Endoplasmic reticulum resident protein 29 ↓	P30040	6.77	29.0	10	37.2	1124
51	C1QBP	Complement component 1 Q subcomponent-binding protein, mitochondrial ↓	Q07021	4.74	31.4	4	13.8	228
52	CBX1	Chromobox protein homolog 1 ↓	P83916	4.85	21.4	10	34.6	1144
53	GUK1	Guanylate kinase ↓	Q16774	6.11	21.7	5	26.9	98
54	COX5A	Cytochrome c oxidase subunit 5A, mitochondrial ↓	P20674	6.30	16.8	6	26.0	165
55	MRPL12	39S ribosomal protein L12, mitochondrial ↓	P52815	9.05	21.3	7	26.8	716
56	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1 ↓	P09651	9.17	38.7	13	41.4	4290
57	PPIB	Peptidyl-prolyl cis–trans isomerase B ↓	P23284	9.42	23.7	16	54.6	2508