Table 4.
Anatomic Distribution of Lymphoproliferations in NSG Mice following PDX Transplantation
| Case | Lung | Esoa | Ton | Thg | Salv | Stom | SI | LI | CNS | BM | Liver | Kid | Spl | LNC | Skin | MC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | + | + | + | + | + | + | − | − | + | + | + | + | − | +b | + | + |
| 2 | + | + | − | + | + | + | − | − | − | + | + | + | + | +b | + | + |
| 3 | + | − | − | − | − | − | − | − | − | − | + | − | + | + | − | − |
| 4c | +d | +d | +d | +d | +d | +d | − | − | − | − | +d | +d | +d | +d | +d | +d |
| 5e | +d | +d | +d | +d | +d | +d | − | − | + | − | +d,f | + | +d,f | + | +d | +d |
| 6e | +d | +d | +d | +d | +d | +d | − | − | + | − | +d,f | − | +d,f | − | +d | +d |
| 7e | +d | +d | +d | +d | +d | +d | − | − | + | +d | +d,f | − | +/minf | n/t | +d | +d |
| 8c | − | − | − | − | − | − | − | − | +d | − | +d,f | − | +d,f | − | − | − |
| 9 | + | + | + | + | + | + | + | − | + | − | + | + | + | +b | + | + |
| 10 | +/min | − | − | − | − | − | − | − | − | − | +/min | − | − | n/t | + | − |
| 11 | + | − | − | + | + | − | + | − | + | − | + | + | + | +b | + | + |
| Total | 11 | 8 | 6 | 8 | 8 | 7 | 2 | 0 | 7 | 3 | 11 | 6 | 9 | 7 | 9 | 8 |
Abbreviation n/t: no tissue available
a:
Eso: Esophagus, Ton: tongue, Thg: thyroid gland, Salv: salivary gland, Stom: stomach, SI: small intestines, LI: large intestines, CNS: central nervous system, BM: bone marrow, Kid: kidney, Spl spleen, LNC: cervical lymph node, MC: mucocutaneous junctions; min: minimal infiltration of tissue by immune cells
b:
sclerosis observed
c:
monomorphic PTLD
d:
PTLD present
e:
polymorphic PTLD
f:
EBV-positive by ISH
PTLD: post-transplantation lymphoproliferative disorder, PDX: patient derived xenograft, EBER: EBV-encoded small RNAs, ISH: in situ hybridization