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. 2020 Aug 19;44(4):166–175. doi: 10.3906/biy-2001-5

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Copyright © 2020 The Author(s)

This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.

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Photomicrographs of testes sections stained with hematoxylin and eosin staining (H&E, 200x). Young control (a), Aged control (b and c), Aged+Ta-65 (d), Aged+pomegranate (e). The testis of young rats showed average-sized tubules with full spermatogenesis (T) with an average interstitium (arrow). The aged rats had testis with mildly thickened tunica albuginea (arrow head) and average-sized tubules (T) with detached germinal lining (d) and average interstitium (arrow) (b). In addition, a widely-separated distorted partially sclerotic tubule (T) could be seen, other tubules showed mildly desquamated germinal cells (G) with dilated interstitial blood vessel (V) (c). Oral administration of Ta-65 to aged rats showed testis with showing average tubules with average germinal lining (T) and average interstitium (arrow). Testis of rats treated with pomegranate revealed average tunica albuginea (arrow head), average-sized tubules with detached germinal lining (d) and mild interstitial edema (arrow).