Fig. 3. Different structural modifications made to the S-MGB framework. The tail group (green) varies in basicity and lipophilicity with the exchange of dimethylaminopropyl with ethyl-morpholine. The first heterocycle (pink) can be either a substituted thiazole or N-methylpyrrole, which has a drastic effect on the overall lipophilicity of the molecule. Various head groups (red) and head group linkers (blue) have been experimented with which, again, has a significant effect on the overall physicochemical properties of the molecule as well as having an impact on DNA binding.