Table 2. Induction of DNA double strand break in the MDA-MB-231 breast cancer cell line.
Compound | Concentration (μM) | Average γH2AX (% of cells) | SD |
Control | 6.1 | 0.7 | |
Camptothecin | 1 | 73.6 | 0.6 |
TOTA | 10 | 43.6 | 0.6 |
Pr-ADOTA | 10 | 27.8 | 3.0 |
Pr-DAOTA | 10 | 2.4 | 2.3 |
TOTA | 5 | 57.5 | 1.3 |
Pr-ADOTA | 5 | 30.6 | 0.9 |
Pr-DAOTA | 5 | 1.3 | 0.2 |
TOTA | 1 | 8.8 | 0.7 |
Pr-ADOTA | 1 | 12.9 | 1.9 |
Pr-DAOTA | 1 | 13.6 | 1.1 |