Table 2. Data obtained from murine in vivo pharmacokinetic study, concentrations of 5a and 5f (IV (1 mg kg^–1) and PO (10 mg kg^–1)). Data represented graphically in Fig. 4 .

Entry	Compound	EC50 ave./μM	Mouse PK (IV)				Mouse PK (PO)
			Cl/mL min–1 kg–1	T 1/2/h	VSS/L kg–1	UC (0-inf)/ng h mL–1	T max/h	C max/ng mL–1	F%	UC (0-inf)/ng h mL–1
1		7.7	207	0.66	11.6	80.5	0.5	283	95.8	711
2		7.7	58	1.14	4.62	289	1	404	58.5	1696