Table 3.
Mean Baseline Cardiometabolic Profiles and Mean Percent Changes from Baseline After Six and Twelve Weeks
| Variable | Baseline (N = 40) | Week 6 (% change) | P value | Week 12 (% change) | P value | P-trenda |
|---|---|---|---|---|---|---|
| Anthropometrica | ||||||
| Weight (kg) | 73.2 ± 1.55 | −1.79 (−2.46 to −1.13) | <.0001 | −2.12 (−3.13 to −1.10) | .0001 | <.0001 |
| BMI (kg/m2) | 27.7 ± 0.560 | −1.80 (−2.48 to −1.11) | <.0001 | −2.33 (−3.68 to −0.982) | .0012 | <.0001 |
| Waist (cm) | 93.8 ± 1.31 | −2.20 (−3.12 to −1.27) | <.0001 | −3.25 (−4.26 to −2.24) | <.0001 | <.0001 |
| Hip (cm) | 105.0 ± 1.329 | −1.39 (−2.15 to −0.639 | .0006 | −1.81 (−2.87 to −0.753) | .0013 | <.0001 |
| Waist/hip | 0.896 ± 0.0121 | −0.845 (−1.92 to 0.233) | .1208 | −1.50 (−2.78 to −0.233) | .0234 | .0081 |
| Index of central obesity | 0.577 ± 0.00867 | −2.16 (−3.03 to −1.29) | <.0001 | −3.25 (−4.21 to −2.29) | <.0001 | <.0001 |
| Glycemica | ||||||
| HbA1c (%) | 6.95 ± 0.272 | — | — | −5.65 (−8.59 to −2.85) | .0002 | NC |
| FBG (mg/dL) | 131 ± 7.49 | −9.31 (−18.1 to −0.420) | .0405 | −6.95 (−15.0 to 1.05) | .0866 | .1034 |
| PPBG (mg/dL) | 193 ± 11.3 | −7.46 (−16.4 to 1.52) | .1012 | −8.39 (−16.2 to 0.663) | .0341 | .0465 |
| eAG (mg/dL) | 153 ± 7.82 | — | — | −7.39 (−11.1 to −3.71) | .0002 | NC |
| Vasculara | ||||||
| SBP (mmHg) | 123 ± 1.55 | −0.285 (−1.42 to 0.854) | .6149 | 0.992 (−1.33 to 3.32) | .3911 | .3129 |
| DBP (mmHg) | 79.4 ± 1.31 | −1.07 (−3.26 to 1.12) | .3285 | −1.45 (−5.88 to 2.98) | .5131 | .4239 |
| MAP (mmHg) | 94.0 ± 1.27 | −0.734 (−2.17 to 0.704) | .3085 | −0.381 (−3.35 to 2.59) | .7969 | .7563 |
| PP (mmHg) | 43.8a ± 1.19 | 1.14 (−5.87 to 8.15) | .7465 | 5.43 (−1.58 to 12.42) | .1275 | .1275 |
| Lipidica | ||||||
| TC (mg/dL) | 203 ± 5.61 | — | — | −7.88 (−12.4 to −3.33) | .0012 | NC |
| TC-HDL (mg/dL) | 163 ± 5.49 | — | — | −9.39 (−15.9 to −3.77) | .0016 | NC |
| LDL (mg/dL) | 130 ± 4.96 | — | — | −6.68 (−13.6 to 0.304) | .0603 | NC |
| VLDL (mg/dL) | 30.2 ± 1.29 | — | — | −11.1 (−17.9 to −4.30) | .0020 | NC |
| HDL (mg/dL) | 39.3 ± 0.416 | — | — | −1.91 (−4.1 to 0.270) | .0842 | NC |
| TG (mg/dL) | 152 ± 6.61 | — | — | −9.21 (−14.9 to −3.51) | .0022 | NC |
| Lipidic ratiosa | ||||||
| TC/HDL | 5.16 ± 0.137 | — | — | −5.85 (−10.5 to −1.15) | .0161 | NC |
| LDL/HDL | 3.31 ± 0.119 | — | — | −4.23 (−11.1 to 2.61) | .2189 | NC |
| VLDL/HDL | 0.769 ± 0.0325 | — | — | −9.44 (−16.9 to −1.94) | .0150 | NC |
| TG/HDL | 3.87 ± 0.166 | — | — | −7.44 (−13.7 to −1.18) | .0211 | NC |
| Hepatica | ||||||
| GGT (IU/L) | 17.7 ± 0.849 | — | — | −13.5 (−22.5 to −4.37) | .0048 | NC |
| AST (mg/dL) | 32.1 ± 1.93 | — | — | −16.5 (−24.8 to −8.15) | .0003 | NC |
| ALT (mg/dL) | 36.0 ± 1.98 | — | — | −17.8 (−26.1 to −9.42) | <.0001 | NC |
| AST/ALT | 0.912 ± 0.0369 | — | — | 2.47 (−5.19 to 10.1) | .6564 | NC |
| ALP (mg/dL) | 162 ± 7.45 | — | — | −12.7 (−18.3 to −6.92) | <.0001 | NC |
| Bilirubin (mg/dL) | 0.640 ± 0.0354 | — | — | −16.1 (−27.8 to −4.17) | .0093 | NC |
| Direct bilirubin (mg/dL) | 0.218 ± 0.0160 | — | — | −6.88 (−25.6 to 11.8) | .4602 | NC |
| Protein (mg/dL) | 6.73 ± 0.0659 | — | — | −1.45 (−3.06 to 0.171) | .0781 | NC |
| Albumin (g/dL) | 4.34 ± 0.0693 | — | — | −3.06 (−5.09 to −1.01) | .0044 | NC |
| Globulin (g/dL) | 2.38 ± 0.0520 | — | — | 1.89 (−2.72 to 6.51) | .4123 | NC |
| Albumin/globulin | 1.87 ± 0.0737 | — | — | −5.88 (−13.1 to 1.35) | .1078 | NC |
| Renala | ||||||
| Urea (mg/dL) | 25.1 ± 0.892 | — | — | −5.78 (−12.2 to 0.637) | .6564 | NC |
| Creatinine (mg/dL) | 0.948 ± 0.0218 | — | — | −1.05 (−5.81 to 3.70) | .6564 | NC |
| Urea/creatinine | 26.9 ± 1.18 | — | — | −5.95 (−13.3 to 1.36) | .6564 | NC |
| Thyroida | ||||||
| T3 (ng/mL) | 1.17 ± 0.0318 | — | — | −0.206 (−5.60 to 5.18) | .9389 | NC |
| T4 (mg/dL) | 7.89 ± 0.319 | — | — | 1.16 (−3.05 to 5.36) | .5812 | NC |
| TSH (mg/dL) | 3.21 ± 0.291 | — | — | −2.07 (−17.0 to 12.9) | .7803 | NC |
a
Baseline values are mean ± SEM; differences from baseline were determined by paired-t or repeated measures ANOVA and are represented as mean percent difference from baseline with parenthetic 95% confidence interval; P-trend represents result of analysis for nonzero slope over 12 weeks.
NC, not calculated.