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. 2020 Aug;23(8):1065–1077. doi: 10.22038/ijbms.2020.46654.10762

Figure 5.

Therapeutic effects of liposomal nanovaccine in combination with anti PD-1 mAb

Figure 5

Immune responses followed combination therapy in TME. (S5A) Representative dot plots demonstrating the gating strategies for flow cytometric analysis of CD3+ T cells and regulatory TILs. (B) Frequency of CD3+ cells indicating TILs, (C) Frequency of CD8 in CD3+ gated TILs, (D) Frequency of PD-1 in CD8+ TILs, (E) Frequency of IFN-γ in CD8+ TILs. (F) Frequency of CD4 in CD3+ gated TILs, (G) Frequency of PD-1 in CD4+ TILs, (H) Frequency of IFN-γ in CD4+ TILs, (I) Frequency of IL-4 in CD4+ TILs. (J) Frequency of CD4/CD25/Foxp3+ TILs, (K) Frequency of IL-10 in Foxp3+ gated TILs. Results represented as Mean±SD; N=3. * P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001 indicated as statistically significant differences