Figure 5.

Representative H&E staining of rat synovial membrane of different groups: the membrane of C group consists of thin synovial intima (black arrow), and subintima with predominance of adipocytes (AD). The synovial membrane of OA group appeared moderately thickened with a disorganized intima (black arrow) and, the subintima, excessive fibrous tissue (asterisk) with few adipocytes (AD) and blood vessels full of red blood cells (HE). The synovial membranes of both OA/Dic and OA/LC groups, showed intimal tissue organization (black arrow), although the subintima appeared moderately fibrous (asterisk). OA/Dic+LC group, histopathological changes were considerably ameliorated with mild irregularity of the synovial intimal layer (black arrow) and remarkable reduction in the subintimal fibrous tissue with appearance of abundant adipocytes (AD). Scale bar 50 µM, ×200

C: Control, OA: Osteoarthritis, OA/Dic: Osteoarthritis/Diclofenac sodium treated, OA/LC: Osteoarthritis/L-carnitine treated, OA/Dic+LC: Osteoarthritis/Diclofenac sodium + L-carnitine treated