Table 1.
Renal functional changes 48 hr after ischemia-reperfusion in rats, and the therapeutic effect of adipose-derived mesenchymal stem cells on them
| Parameter | Control | Sham 48hr | I/R48hr+PBS | I/R48hr+stem cell |
|---|---|---|---|---|
| Plasma creatinine concentration (mg/dl) | 0.52 ± 0.014 | 0.57 ±0.008 | 2.37 ± 0.13 *** |
0.94 ± 0.07 ***††† |
| Blood urea nitrogen (mg/dl) | 23.6 ± 1.65 | 24.12 ± 0.83 | 84 ± 6.29 *** |
34.12 ± 2.66 ††† |
| Absolute urinary sodium excretion (mmol/min/kg) | 2.56 ± 0.49 | 1.81 ± 0.36 | 3.73 ± 0.68 ** |
3.87 ± 0.57 ** |
| Absolute urinary potassium excretion (mmol/min/kg) | 4.01 ± 0.96 | 2.82 ± 0.59 | 2.9 ± 0.63 | 3.48 ± 0.68 |
| Fraction urinary sodium exertion (mmol/min/kg) | 1.33 ± 0.3 | 0.72 ± 0.07 | 7.07 ± 1.35 *** |
1.46 ± 0.14 ††† |
| Fraction urinary potassium exertion (mmol/min/kg) | 72.19 ± 25.74 | 33.6 ± 1.75 | 130.42 ± 18.72 ** |
43.5 ± 5.22 †† |
| Urine osmolarity (mOsm/kg H2O) |
1751.7 ± 119.64 | 1969.7 ± 144.2 | 744.8 ± 89.13 *** |
1231.11 ± 105.11 *** †† |
| Creatinine clearance (ml/min/kg) |
1.67 ± 0.38 | 1.66 ±0.3 | 0.54 ± 0.17 ** |
1.86 ± 0.21†† |
**P<0.01, ***P<0.001 in comparison with the sham group
††P<0.01, †††P<0.001 in comparison with the I/R group
IR: ischemia-reperfusion