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. 2020 Aug;23(8):999–1006. doi: 10.22038/ijbms.2020.40334.9601

Table 2.

Summary of the degree of kidney histopathologic damages induced by 45 min of ischemia followed by 48 hr of reperfusion, and the therapeutic effect of adipose-derived mesenchymal stem cells on them

Histopathologic damages Study groups
Control Sham 48 hr I/R 48hr +PBS I/R 48hr + stem cell
Bowman capsule 0 0.01 3.35 3.65
proximal tubal 0 0 1.61 1.89
thick ascending limb of Henle’s loop 0 0 1.23 1.11
Pars Recta 0 0.01 2.37 1.76
thick ascending limb of Henle’s loop 0 0.02 2.67 2.36
vascular congestion 0 0 1.54 0.78
tubular protein cast 0 0 1.14 0.53
vascular congestion 0 0 1.02 0.51
tubular protein cast 0 0 1.13 0.46
Total histopathologic scale 0 0.04 16.06* 13.05*†

Grades of histopathologic injuries in rats with no intervention (control); rats that underwent laparotomy without clamping of renal vessels and received PBS solution and equivalent 48-hr perfusion period (Sham); rats with 45 min of ischemia and 48 hr of reperfusion that received PBS (I/R 48 hr+ PBS); rats with 45 min of ischemia and 48 hr of reperfusion that had received 2×106 adipose-derived mesenchymal stem cells (I/R 48 hr+stem cell)

*P<0.001 in comparison with the sham group

P<0.01 in comparison with the I/R group

IR: ischemia-reperfusion