Table 2.
Summary of the degree of kidney histopathologic damages induced by 45 min of ischemia followed by 48 hr of reperfusion, and the therapeutic effect of adipose-derived mesenchymal stem cells on them
| Histopathologic damages | Study groups |
|||
|---|---|---|---|---|
| Control | Sham 48 hr | I/R 48hr +PBS | I/R 48hr + stem cell | |
| Bowman capsule | 0 | 0.01 | 3.35 | 3.65 |
| proximal tubal | 0 | 0 | 1.61 | 1.89 |
| thick ascending limb of Henle’s loop | 0 | 0 | 1.23 | 1.11 |
| Pars Recta | 0 | 0.01 | 2.37 | 1.76 |
| thick ascending limb of Henle’s loop | 0 | 0.02 | 2.67 | 2.36 |
| vascular congestion | 0 | 0 | 1.54 | 0.78 |
| tubular protein cast | 0 | 0 | 1.14 | 0.53 |
| vascular congestion | 0 | 0 | 1.02 | 0.51 |
| tubular protein cast | 0 | 0 | 1.13 | 0.46 |
| Total histopathologic scale | 0 | 0.04 | 16.06* | 13.05*† |
Grades of histopathologic injuries in rats with no intervention (control); rats that underwent laparotomy without clamping of renal vessels and received PBS solution and equivalent 48-hr perfusion period (Sham); rats with 45 min of ischemia and 48 hr of reperfusion that received PBS (I/R 48 hr+ PBS); rats with 45 min of ischemia and 48 hr of reperfusion that had received 2×106 adipose-derived mesenchymal stem cells (I/R 48 hr+stem cell)
*P<0.001 in comparison with the sham group
†P<0.01 in comparison with the I/R group
IR: ischemia-reperfusion