Figure 1.

Action-potential characteristics of Pluricyte^® CMs at baseline. (A) Series of spontaneous action potentials with pronounced diastolic depolarization. The injection of computed I_K1 through dynamic clamp led to a resting membrane potential comparable to that of native CMs. (B) Zoom-in of action potential showing a typical native-like contour. The profile of the computed and injected I_K1 is depicted below. (C) Rate dependence of action-potential duration (APD₉₀) (n = 7, 11, 16, 6 CMs for pacing cycle lengths of 333, 500, 1000, and 2000 ms).