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. 2020 Aug 8;22(9):1431–1441. doi: 10.1093/europace/euaa111

Figure 4.

Figure 4

Action-potential effects of IKr block by dofetilide in Pluricyte CMs. (A) Repolarization variability visualized by the shortest and the longest APs with/without EADs in a series of 30 consecutive beats. (B) Poincaré plot of APD90 in a representative cell, showing increased BVR by dofetilide (in the absence of EADs). (C) Average increase in APD90 without EADs (n = 20). (D) Average increase in BVR at baseline and during dofetilide (n = 20). (E) Repolarization prolongation and EAD generation (red traces; 100 nmol/L dofetilide) in a representative cell. (F) Incidence of EADs in 20 cells treated with dofetilide.